Doctor Octopus Synergy Guide

Adding Doctor Octopus with Ant-Man activates the 'Biochemistry' synergy bonus where Doctor Octopus gets to start the fight with 40 Chemistry Research whilst Ant-Man reflects 40% of Physical Damage done by attacks that make contact with his Glancing Hits.

Add Diablo to a team with Doctor Octopus to activate the 'Madcap Experimentalists' synergy bonus where Diablo gets to recover 1 Lifestitch after winning 1 Fight and Doctor Octopus gets +30% Heal Block Debuff duration. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Add Doctor Doom to a team with Doctor Octopus to activate the 'Genius Ingenuity' synergy bonus where Shock and Incinerate Debuffs for Doctor Doom have a +20% increased Potency. Please note this is a solo synergy which does not stack.

Adding Doctor Octopus with Electro activates the 'Particle Physics' synergy bonus where Doctor Octopus has his Research Categories reset to 50 when a Breakthrough expires and Electro gains 50% additional Power from Critical Hits

Add Elsa Bloodstone to a team with Doctor Octopus to activate the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Add M.O.D.O.K. to a team with Doctor Octopus to activate the 'Masterminds' synergy bonus, increasing 'Attack' once a combo of 15 or more hits are reached.

Add Mister Fantastic to a team with Doctor Octopus to activate the 'Shared Knowledge - Robotics' synergy bonus where Tech and Science Champion’s Debuffs also apply an indefinite Power Sting, dealing Direct Damage equal to 60% of their Attack Rating when the Opponent activates a Special Attack. The Power Sting stacks up to 3 times. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Adding Doctor Octopus with Spider-Man (Classic) activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Adding Doctor Octopus with Spider-Man (Stark Enhanced) activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Add Venom to a team with Doctor Octopus to activate the 'Rivals' synergy bonus, increasing 'Critical Damage Rating' for the whole team.

Adding Doctor Octopus with Vulture activates the 'Engineering' synergy bonus where Research Categories for Doctor Octopus no longer fall off over time and Vulture gains an additional +5 Chitauri Charge on a Critical Hit.