
Doctor Octopus Synergy Guide
Doctor Octopus is a Tech class villain champion in the Contest of Champions who forms a synergy with 11 other characters, available as a 2-Star, 3-Star, 4-Star, 5-Star and 6-Star champion.
Otton Octavius came from a troubled home. Determined not to follow in his abusive father's footsteps, Otto devoted himself to his studies. Despite years of derision from his peers, he became a nuclear physicist. But after he had to have the mechanical arms he designed and built surgically removed following an accident Otto finally had enough. Assuming the derogatory name his co-workers had coined for him, Otto began a life of crime as Doctor Octopus.
Synergy Bonuses
- 'Particle Physics' with Electro
- 'Biochemistry' with Ant-Man
- 'Engineering' with Vulture
- 'Nemesis' with Spider-Man (Stark Enhanced) or Spider-Man (Classic)

Ant-Man
Adding Doctor Octopus with Ant-Man activates the 'Biochemistry' synergy bonus where Doctor Octopus gets to start the fight with 40 Chemistry Research whilst Ant-Man reflects 40% of Physical Damage done by attacks that make contact with his Glancing Hits.

Doctor Octopus Synergy with Ant-Man
Star | Synergy | Bonus |
---|---|---|
Doctor Octopus 3 Star | Biochemistry | See Notes |
Doctor Octopus 4 Star | Biochemistry | See Notes |
Doctor Octopus 5 Star | Biochemistry | See Notes |
Doctor Octopus 6 Star | Biochemistry | See Notes |
Diablo
Add Diablo to a team with Doctor Octopus to activate the 'Madcap Experimentalists' synergy bonus where Diablo gets to recover 1 Lifestitch after winning 1 Fight and Doctor Octopus gets +30% Heal Block Debuff duration. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Diablo Synergy with Doctor Octopus
Star | Synergy | Bonus |
---|---|---|
Doctor Octopus 3 Star | Madcap Experimentalists | See Notes |
Doctor Octopus 4 Star | Madcap Experimentalists | See Notes |
Doctor Octopus 5 Star | Madcap Experimentalists | See Notes |
Doctor Octopus 6 Star | Madcap Experimentalists | See Notes |
Doctor Doom
Add Doctor Doom to a team with Doctor Octopus to activate the 'Genius Ingenuity' synergy bonus where Shock and Incinerate Debuffs for Doctor Doom have a +20% increased Potency. Please note this is a solo synergy which does not stack.

Doctor Doom Synergy with Doctor Octopus
Star | Synergy | Bonus |
---|---|---|
Doctor Octopus 4 Star | Genius Ingenuity | See Notes |
Doctor Octopus 5 Star | Genius Ingenuity | See Notes |
Electro
Adding Doctor Octopus with Electro activates the 'Particle Physics' synergy bonus where Doctor Octopus has his Research Categories reset to 50 when a Breakthrough expires and Electro gains 50% additional Power from Critical Hits

Doctor Octopus Synergy with Electro
Star | Synergy | Bonus |
---|---|---|
Doctor Octopus 2 Star | Particle Physics | See Notes |
Doctor Octopus 3 Star | Particle Physics | See Notes |
Doctor Octopus 4 Star | Particle Physics | See Notes |
Doctor Octopus 5 Star | Particle Physics | See Notes |
Doctor Octopus 6 Star | Particle Physics | See Notes |
Elsa Bloodstone
Add Elsa Bloodstone to a team with Doctor Octopus to activate the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Elsa Bloodstone Synergy with Doctor Octopus
Star | Synergy | Bonus |
---|---|---|
Doctor Octopus 3 Star | Enemies Level 2 | +115 Critical Rating |
Doctor Octopus 4 Star | Enemies Level 3 | +155 Critical Rating |
Doctor Octopus 5 Star | Enemies Level 3 | +155 Critical Rating |
M.O.D.O.K.
Add M.O.D.O.K. to a team with Doctor Octopus to activate the 'Masterminds' synergy bonus, increasing 'Attack' once a combo of 15 or more hits are reached.

M.O.D.O.K. Synergy with Doctor Octopus
Star | Synergy | Bonus |
---|---|---|
Doctor Octopus 3 Star | Masterminds Level 1 | +10% Attack |
Doctor Octopus 4 Star | Masterminds Level 2 | +12% Attack |
Doctor Octopus 5 Star | Masterminds Level 2 | +12% Attack |
Doctor Octopus 6 Star | Masterminds Level 2 | +12% Attack |
Mister Fantastic
Add Mister Fantastic to a team with Doctor Octopus to activate the 'Shared Knowledge - Robotics' synergy bonus where Tech and Science Champion’s Debuffs also apply an indefinite Power Sting, dealing Direct Damage equal to 60% of their Attack Rating when the Opponent activates a Special Attack. The Power Sting stacks up to 3 times. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic Synergy with Doctor Octopus
Star | Synergy | Bonus |
---|---|---|
Doctor Octopus 3 Star | Shared Knowledge - Robotics | See Notes |
Doctor Octopus 4 Star | Shared Knowledge - Robotics | See Notes |
Doctor Octopus 5 Star | Shared Knowledge - Robotics | See Notes |
Doctor Octopus 6 Star | Shared Knowledge - Robotics | See Notes |
Spider-Man (Classic)
Adding Doctor Octopus with Spider-Man (Classic) activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Doctor Octopus Synergy with Spider-Man (Classic)
Star | Synergy | Bonus |
---|---|---|
Doctor Octopus 4 Star | Nemesis Level 3 | +6% Attack |
Doctor Octopus 5 Star | Nemesis Level 3 | +6% Attack |
Doctor Octopus 6 Star | Nemesis Level 3 | +6% Attack |
Spider-Man (Stark Enhanced)
Adding Doctor Octopus with Spider-Man (Stark Enhanced) activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Doctor Octopus Synergy with Spider-Man (Stark Enhanced)
Star | Synergy | Bonus |
---|---|---|
Doctor Octopus 4 Star | Nemesis Level 3 | +6% Attack |
Doctor Octopus 5 Star | Nemesis Level 3 | +6% Attack |
Doctor Octopus 6 Star | Nemesis Level 3 | +6% Attack |
Venom
Add Venom to a team with Doctor Octopus to activate the 'Rivals' synergy bonus, increasing 'Critical Damage Rating' for the whole team.

Venom Synergy with Doctor Octopus
Star | Synergy | Bonus |
---|---|---|
Doctor Octopus 3 Star | Rivals Level 2 | +90 Critical Damage Rating |
Doctor Octopus 4 Star | Rivals Level 3 | +115 Critical Damage Rating |
Doctor Octopus 5 Star | Rivals Level 3 | +115 Critical Damage Rating |
Vulture
Adding Doctor Octopus with Vulture activates the 'Engineering' synergy bonus where Research Categories for Doctor Octopus no longer fall off over time and Vulture gains an additional +5 Chitauri Charge on a Critical Hit.

Doctor Octopus Synergy with Vulture
Star | Synergy | Bonus |
---|---|---|
Doctor Octopus 4 Star | Engineering | See Notes |
Doctor Octopus 5 Star | Engineering | See Notes |
Doctor Octopus 6 Star | Engineering | See Notes |