Doctor Octopus Cover

Doctor Octopus Synergy Guide

Doctor Octopus is a Tech class villain champion in the Contest of Champions who forms a synergy with 7 other characters, available as a 2-Star, 3-Star, 4-Star, 5-Star and 6-Star champion.

Otton Octavius came from a troubled home. Determined not to follow in his abusive father's footsteps, Otto devoted himself to his studies. Despite years of derision from his peers, he became a nuclear physicist. But after he had to have the mechanical arms he designed and built surgically removed following an accident Otto finally had enough. Assuming the derogatory name his co-workers had coined for him, Otto began a life of crime as Doctor Octopus.

Synergy Bonuses

Synergy Partners

  • Ant-ManAnt-Man
  • DiabloDiablo
  • ElectroElectro
  • M.O.D.O.K.M.O.D.O.K.
  • Spider-Man (Stark Enhanced)Spider-Man (Stark Enhanced)
  • VenomVenom
  • VultureVulture
Doctor Octopus


Ant-Man

Adding Doctor Octopus with activates the 'Biochemistry' synergy bonus where Doctor Octopus gets to start the fight with 40 Chemistry Research whilst Ant-Man reflects 40% of Physical Damage done by attacks that make contact with his Glancing Hits.

Doctor Octopus

Doctor Octopus Synergy with Ant-Man

Star Synergy Bonus
Doctor Octopus 3 Star Biochemistry See Notes
Doctor Octopus 4 Star Biochemistry See Notes
Doctor Octopus 5 Star Biochemistry See Notes
Doctor Octopus 6 Star Biochemistry See Notes

Diablo

Add to a team with Doctor Octopus to activate the 'Madcap Experimentalists' synergy bonus where Diablo gets to recover 1 Lifestitch after winning 1 Fight and Doctor Octopus gets +30% Heal Block Debuff duration. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Diablo

Diablo Synergy with Doctor Octopus

Star Synergy Bonus
Diablo 3 Star Madcap Experimentalists See Notes
Diablo 4 Star Madcap Experimentalists See Notes
Diablo 5 Star Madcap Experimentalists See Notes
Diablo 6 Star Madcap Experimentalists See Notes

Electro

Adding Doctor Octopus with activates the 'Particle Physics' synergy bonus where Doctor Octopus has his Research Categories reset to 50 when a Breakthrough expires and Electro gains 50% additional Power from Critical Hits

Doctor Octopus

Doctor Octopus Synergy with Electro

Star Synergy Bonus
Doctor Octopus 2 Star Particle Physics See Notes
Doctor Octopus 3 Star Particle Physics See Notes
Doctor Octopus 4 Star Particle Physics See Notes
Doctor Octopus 5 Star Particle Physics See Notes
Doctor Octopus 6 Star Particle Physics See Notes

M.O.D.O.K.

Add to a team with Doctor Octopus to activate the 'Masterminds' synergy bonus, increasing 'Attack' once a combo of 15 or more hits are reached.

M.O.D.O.K.

M.O.D.O.K. Synergy with Doctor Octopus

Star Synergy Bonus
M.O.D.O.K. 3 Star Masterminds Level 1 +10% Attack
M.O.D.O.K. 4 Star Masterminds Level 2 +12% Attack
M.O.D.O.K. 5 Star Masterminds Level 2 +12% Attack
M.O.D.O.K. 6 Star Masterminds Level 2 +12% Attack

Spider-Man (Stark Enhanced)

Adding Doctor Octopus with activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Doctor Octopus

Doctor Octopus Synergy with Spider-Man (Stark Enhanced)

Star Synergy Bonus
Doctor Octopus 4 Star Nemesis Level 3 +6% Attack
Doctor Octopus 5 Star Nemesis Level 3 +6% Attack
Doctor Octopus 6 Star Nemesis Level 3 +6% Attack

Venom

Add to a team with Doctor Octopus to activate the 'Rivals' synergy bonus, increasing 'Critical Damage Rating' for the whole team.

Venom

Venom Synergy with Doctor Octopus

Star Synergy Bonus
Venom 3 Star Rivals Level 2 +90 Critical Damage Rating
Venom 4 Star Rivals Level 3 +115 Critical Damage Rating
Venom 5 Star Rivals Level 3 +115 Critical Damage Rating

Vulture

Adding Doctor Octopus with activates the 'Engineering' synergy bonus where Research Categories for Doctor Octopus no longer fall off over time and Vulture gains an additional +5 Chitauri Charge on a Critical Hit.

Doctor Octopus

Doctor Octopus Synergy with Vulture

Star Synergy Bonus
Doctor Octopus 4 Star Engineering See Notes
Doctor Octopus 5 Star Engineering See Notes
Doctor Octopus 6 Star Engineering See Notes