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Mister Fantastic Synergy Guide

Mister Fantastic is a Science class champion in the Contest of Champions who forms a synergy with 21 other characters, available as a 3-Star, 4-Star, 5-Star and 6-Star champion.

Reed Richards is a brilliant scientist, who spearheaded an experimental voyage into space accompanied by his friends and family. An accident occurred during the trip, and the ship was flooded with cosmic rays. After crashing back to Earth, Reed found that he could stretch and elongate his body in impossible ways. He became the leader of the Fantastic Four, and uses his powers of elasticity and his genius intellect to deftly handle all threats, galactic to microscopic.

Synergy Bonuses

Synergy Partners

  • Angela
  • Doctor Doom
  • Doctor Octopus
  • Doctor Strange
  • Gamora
  • Groot
  • Hulkbuster
  • Human Torch
  • Invisible Woman
  • Loki
  • Masacre
  • Mister Fantastic
  • Mole Man
  • Night Thrasher
  • Psylocke
  • Sentry
  • She-Hulk
  • Silver Surfer
  • Storm
  • Thing
  • Vulture
Mister Fantastic

Angela

Adding Mister Fantastic with activates the 'Shared Knowledge - Astronomy' synergy bonus where Cosmic and Skill Champion’s Basic Hits pause one of each Buff on them for 0.2 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic

Mister Fantastic Synergy with Angela

Star Synergy Bonus
Mister Fantastic 3 Star Shared Knowledge - Astronomy See Notes
Mister Fantastic 4 Star Shared Knowledge - Astronomy See Notes
Mister Fantastic 5 Star Shared Knowledge - Astronomy See Notes
Mister Fantastic 6 Star Shared Knowledge - Astronomy See Notes
Please note: Mister Fantastic can also activate 'Shared Knowledge - Astronomy' with Groot, Masacre or Night Thrasher as an alternative.
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Doctor Doom

Team up Mister Fantatic with the to activate multiple synergies. Doctor Doom activates the 'Genius Ingenuity' solo synergy (does not stack) where his Shock and Incinerate Debuffs have a +20% increased Potency and in addition he also activates the 'Nemesis' synergy which increases 'Attack' for the whole team. Mister Fantatic activates the unique synergy 'College Rivals' where he gains 5% of his Max Power each time a Buff is Nullified or its Duration expires off the Opponent and Heavy Attacks for Doctor Doom apply up to 1 Armor Break Debuff for 10 seconds, reducing Armor Rating by 15%.

Mister Fantastic

Mister Fantastic Synergy with Doctor Doom

Star Synergy Bonus
Mister Fantastic 3 Star College Rivals See Notes
Mister Fantastic 4 Star College Rivals See Notes
Mister Fantastic 5 Star College Rivals See Notes
Mister Fantastic 6 Star College Rivals See Notes
Doctor Doom

Doctor Doom Synergy with Mister Fantastic

Star Synergy Bonus
Mister Fantastic 3 Star Nemesis Level 2 +5% Attack
Mister Fantastic 4 Star Nemesis Level 3 + Genius Ingenuity +6% Attack + See Notes
Mister Fantastic 5 Star Nemesis Level 3 + Genius Ingenuity +6% Attack + See Notes
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Doctor Octopus

Adding Mister Fantastic with activates the 'Shared Knowledge - Robotics' synergy bonus where Tech and Science Champion’s Debuffs also apply an indefinite Power Sting, dealing Direct Damage equal to 60% of their Attack Rating when the Opponent activates a Special Attack. The Power Sting stacks up to 3 times. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic

Mister Fantastic Synergy with Doctor Octopus

Star Synergy Bonus
Mister Fantastic 3 Star Shared Knowledge - Robotics See Notes
Mister Fantastic 4 Star Shared Knowledge - Robotics See Notes
Mister Fantastic 5 Star Shared Knowledge - Robotics See Notes
Mister Fantastic 6 Star Shared Knowledge - Robotics See Notes
Please note: Mister Fantastic can also activate 'Shared Knowledge - Robotics' with Sentry, She-Hulk or Vulture as an alternative.
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Doctor Strange

Adding Mister Fantastic with activates the 'Shared Knowledge - Genetics' synergy bonus where Mutant and Mystic Champions regain 5% of the Power spent on any Special Attack, for each unique Special Attack they’ve used in the fight. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic

Mister Fantastic Synergy with Doctor Strange

Star Synergy Bonus
Mister Fantastic 3 Star Shared Knowledge - Genetics See Notes
Mister Fantastic 4 Star Shared Knowledge - Genetics See Notes
Mister Fantastic 5 Star Shared Knowledge - Genetics See Notes
Mister Fantastic 6 Star Shared Knowledge - Genetics See Notes
Please note: Mister Fantastic can also activate 'Shared Knowledge - Genetics' with Psylocke, Storm or Loki as an alternative.
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Gamora

Add to a team with Mister Fantastic to activate the 'Cybernetics Upgrade - Assault' synergy bonus where Gamora gains +20% Fury & Cruelty Buff Potency. This is a Solo synergy which does not stack.

Gamora

Gamora Synergy with Mister Fantastic

Star Synergy Bonus
Mister Fantastic 4 Star Cybernetics Upgrade - Assault See Notes
Mister Fantastic 6 Star Cybernetics Upgrade - Assault See Notes
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Groot

Adding Mister Fantastic with activates the 'Shared Knowledge - Astronomy' synergy bonus where Cosmic and Skill Champion’s Basic Hits pause one of each Buff on them for 0.2 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic

Mister Fantastic Synergy with Groot

Star Synergy Bonus
Mister Fantastic 3 Star Shared Knowledge - Astronomy See Notes
Mister Fantastic 4 Star Shared Knowledge - Astronomy See Notes
Mister Fantastic 5 Star Shared Knowledge - Astronomy See Notes
Mister Fantastic 6 Star Shared Knowledge - Astronomy See Notes
Please note: Mister Fantastic can also activate 'Shared Knowledge - Astronomy' with Angela, Masacre or Night Thrasher as an alternative.
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Hulkbuster

Add to a team with Mister Fantastic to activate the 'Engineering Experts' synergy bonus where each Shock Debuff for Hulkbuster reduces the opponent's Offensive Ability Accuracy during Special Attacks by 15% and Mister Fantastic gets +1000 Physical Resistance. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Hulkbuster

Hulkbuster Synergy with Mister Fantastic

Star Synergy Bonus
Mister Fantastic 4 Star Engineering Experts See Notes
Mister Fantastic 5 Star Engineering Experts See Notes
Mister Fantastic 6 Star Engineering Experts See Notes
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Human Torch

Team up Mister Fantatic with the to activate up to three unique synergies which do not stack. Human Torch activates the 'Rain of Fire' synergy where the last hit of Special Attack 1 Incinerates the Opponent for 6 seconds for other Synergy Members and if all are present it also adds Heal block.
Mister Fantastic activates 'H.E.R.B.I.E.' where Other Synergy Members heal 10% of Max Health over 6 seconds if at or below 20% health at the start of the fight, otherwise gain 60% of a Bar of Power over 6 seconds instead.
If all of the Fantastic Four are in the team the unique synergy is activated where Incinerate and Nova Flame duration is increased by 30% for the Human Torch and for Mister Fantatic with each unique Debuff on the Opponent they take 4% of Mister Fantastic’s current Attack Rating as Direct Damage per second.

Mister Fantastic

Mister Fantastic Synergy with Human Torch

Star Synergy Bonus
Mister Fantastic 3 Star H.E.R.B.I.E. See Notes
Mister Fantastic 4 Star H.E.R.B.I.E. + The Fantastic Four See Notes
Mister Fantastic 5 Star H.E.R.B.I.E. + The Fantastic Four See Notes
Mister Fantastic 6 Star H.E.R.B.I.E. + The Fantastic Four See Notes
Human Torch

Human Torch Synergy with Mister Fantastic

Star Synergy Bonus
Mister Fantastic 3 Star Rain of Fire See Notes
Mister Fantastic 4 Star Rain of Fire See Notes
Mister Fantastic 5 Star Rain of Fire See Notes
Mister Fantastic 6 Star Rain of Fire See Notes
Please note: Mister Fantastic can also activate 'H.E.R.B.I.E.' with Thing or Invisible Woman as an alternative. Mister Fantastic can also activate 'The Fantastic Four' with Thing or Invisible Woman as an alternative.
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Invisible Woman

Team up Mister Fantatic with the to activate up to five unique synergies which do not stack. Invisible Woman activates 'Force Block' which increases Block Proficiency by 5% and Perfect Block chance by 10% for other synergy members plus if you’ve teamed all the other Champions in the synergy, then Well-Timed Blocks inflict up to one 10% Weakness Debuff on the Opponent for 6 seconds. The Invisible Woman also activates the 'Till Death…' synergy so that when the Opponent activates a Special Attack, if the Force Field is active, it gains 10% strength for each Bar of Power spent.
Mister Fantastic activates '… Do Us Part' which makes his Debuffs last 25% longer and also 'H.E.R.B.I.E.' where Other Synergy Members heal 10% of Max Health over 6 seconds if at or below 20% health at the start of the fight, otherwise gain 60% of a Bar of Power over 6 seconds instead.
If all of the Fantastic Four are in the team the unique synergy is activated where Invisibility for Invisible Woman only has a 15% chance to unpause during a Well-Timed Block and for Mister Fantatic with each unique Debuff on the Opponent they take 4% of Mister Fantastic’s current Attack Rating as Direct Damage per second.

Mister Fantastic

Mister Fantastic Synergy with Invisible Woman

Star Synergy Bonus
Mister Fantastic 3 Star H.E.R.B.I.E. + …Do Us Part See Notes
Mister Fantastic 4 Star H.E.R.B.I.E. + The Fantastic Four + …Do Us Part See Notes
Mister Fantastic 5 Star H.E.R.B.I.E. + The Fantastic Four + …Do Us Part See Notes
Mister Fantastic 6 Star H.E.R.B.I.E. + The Fantastic Four + …Do Us Part See Notes
Invisible Woman

Invisible Woman Synergy with Mister Fantastic

Star Synergy Bonus
Mister Fantastic 3 Star Force Block + Till Death… See Notes
Mister Fantastic 4 Star Force Block + Till Death… See Notes
Mister Fantastic 5 Star Force Block + Till Death… See Notes
Mister Fantastic 6 Star Force Block + Till Death… See Notes
Please note: Mister Fantastic can also activate 'H.E.R.B.I.E.' with Thing or Human Torch as an alternative. Mister Fantastic can also activate 'The Fantastic Four' with Thing or Human Torch as an alternative.
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Loki

Adding Mister Fantastic with activates the 'Shared Knowledge - Genetics' synergy bonus where Mutant and Mystic Champions regain 5% of the Power spent on any Special Attack, for each unique Special Attack they’ve used in the fight. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic

Mister Fantastic Synergy with Loki

Star Synergy Bonus
Mister Fantastic 3 Star Shared Knowledge - Genetics See Notes
Mister Fantastic 4 Star Shared Knowledge - Genetics See Notes
Mister Fantastic 5 Star Shared Knowledge - Genetics See Notes
Mister Fantastic 6 Star Shared Knowledge - Genetics See Notes
Please note: Mister Fantastic can also activate 'Shared Knowledge - Genetics' with Psylocke, Storm or Doctor Strange as an alternative.
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Masacre

Adding Mister Fantastic with activates the 'Shared Knowledge - Astronomy' synergy bonus where Cosmic and Skill Champion’s Basic Hits pause one of each Buff on them for 0.2 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic

Mister Fantastic Synergy with Masacre

Star Synergy Bonus
Mister Fantastic 3 Star Shared Knowledge - Astronomy See Notes
Mister Fantastic 4 Star Shared Knowledge - Astronomy See Notes
Mister Fantastic 5 Star Shared Knowledge - Astronomy See Notes
Mister Fantastic 6 Star Shared Knowledge - Astronomy See Notes
Please note: Mister Fantastic can also activate 'Shared Knowledge - Astronomy' with Groot, Angela or Night Thrasher as an alternative.
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Mister Fantastic

A totally unique synergy for Mister Fantastic, 'Council of Reeds' increases Attack Rating by 0% however the potency of this synergy is increased by a flat 30% for each other Mister Fantastic on your team.

Mister Fantastic

Mister Fantastic Synergy with Mister Fantastic

Star Synergy Bonus
Mister Fantastic 3 Star Council of Reeds See Notes
Mister Fantastic 4 Star Council of Reeds See Notes
Mister Fantastic 5 Star Council of Reeds See Notes
Mister Fantastic 6 Star Council of Reeds See Notes
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Mole Man

Add to a team with Mister Fantastic to activate the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Mole Man

Mole Man Synergy with Mister Fantastic

Star Synergy Bonus
Mister Fantastic 3 Star Enemies Level 1 +85 Critical Rating
Mister Fantastic 4 Star Enemies Level 2 +115 Critical Rating
Mister Fantastic 5 Star Enemies Level 3 +155 Critical Rating
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Night Thrasher

Adding Mister Fantastic with activates the 'Shared Knowledge - Astronomy' synergy bonus where Cosmic and Skill Champion’s Basic Hits pause one of each Buff on them for 0.2 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic

Mister Fantastic Synergy with Night Thrasher

Star Synergy Bonus
Mister Fantastic 3 Star Shared Knowledge - Astronomy See Notes
Mister Fantastic 4 Star Shared Knowledge - Astronomy See Notes
Mister Fantastic 5 Star Shared Knowledge - Astronomy See Notes
Mister Fantastic 6 Star Shared Knowledge - Astronomy See Notes
Please note: Mister Fantastic can also activate 'Shared Knowledge - Astronomy' with Groot, Angela or Masacre as an alternative.
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Psylocke

Adding Mister Fantastic with activates the 'Shared Knowledge - Genetics' synergy bonus where Mutant and Mystic Champions regain 5% of the Power spent on any Special Attack, for each unique Special Attack they’ve used in the fight. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic

Mister Fantastic Synergy with Psylocke

Star Synergy Bonus
Mister Fantastic 3 Star Shared Knowledge - Genetics See Notes
Mister Fantastic 4 Star Shared Knowledge - Genetics See Notes
Mister Fantastic 5 Star Shared Knowledge - Genetics See Notes
Mister Fantastic 6 Star Shared Knowledge - Genetics See Notes
Please note: Mister Fantastic can also activate 'Shared Knowledge - Genetics' with Storm, Doctor Strange or Loki as an alternative.
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Sentry

Adding Mister Fantastic with activates the 'Shared Knowledge - Robotics' synergy bonus where Tech and Science Champion’s Debuffs also apply an indefinite Power Sting, dealing Direct Damage equal to 60% of their Attack Rating when the Opponent activates a Special Attack. The Power Sting stacks up to 3 times. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic

Mister Fantastic Synergy with Sentry

Star Synergy Bonus
Mister Fantastic 3 Star Shared Knowledge - Robotics See Notes
Mister Fantastic 4 Star Shared Knowledge - Robotics See Notes
Mister Fantastic 5 Star Shared Knowledge - Robotics See Notes
Mister Fantastic 6 Star Shared Knowledge - Robotics See Notes
Please note: Mister Fantastic can also activate 'Shared Knowledge - Robotics' with She-Hulk, Vulture or Doctor Octopus as an alternative.
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She-Hulk

Adding Mister Fantastic with activates the 'Shared Knowledge - Robotics' synergy bonus where Tech and Science Champion’s Debuffs also apply an indefinite Power Sting, dealing Direct Damage equal to 60% of their Attack Rating when the Opponent activates a Special Attack. The Power Sting stacks up to 3 times. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic

Mister Fantastic Synergy with She-Hulk

Star Synergy Bonus
Mister Fantastic 3 Star Shared Knowledge - Robotics See Notes
Mister Fantastic 4 Star Shared Knowledge - Robotics See Notes
Mister Fantastic 5 Star Shared Knowledge - Robotics See Notes
Mister Fantastic 6 Star Shared Knowledge - Robotics See Notes
Please note: Mister Fantastic can also activate 'Shared Knowledge - Robotics' with Sentry, Vulture or Doctor Octopus as an alternative.
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Silver Surfer

Add to a team with Mister Fantastic to activate the 'Friends' synergy bonus, increasing 'Armor Rating' for the whole team.

Silver Surfer

Silver Surfer Synergy with Mister Fantastic

Star Synergy Bonus
Mister Fantastic 3 Star Friends Level 1 +70 Armor Rating
Mister Fantastic 4 Star Friends Level 2 +95 Armor Rating
Mister Fantastic 5 Star Friends Level 3 +130 Armor Rating
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Storm

Adding Mister Fantastic with activates the 'Shared Knowledge - Genetics' synergy bonus where Mutant and Mystic Champions regain 5% of the Power spent on any Special Attack, for each unique Special Attack they’ve used in the fight. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic

Mister Fantastic Synergy with Storm

Star Synergy Bonus
Mister Fantastic 3 Star Shared Knowledge - Genetics See Notes
Mister Fantastic 4 Star Shared Knowledge - Genetics See Notes
Mister Fantastic 5 Star Shared Knowledge - Genetics See Notes
Mister Fantastic 6 Star Shared Knowledge - Genetics See Notes
Please note: Mister Fantastic can also activate 'Shared Knowledge - Genetics' with Psylocke, Doctor Strange or Loki as an alternative.
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Thing

Team up Mister Fantatic with the to activate up to three unique synergies which do not stack. Thing activates the 'The Brave and the Boulder' which makes where the last hit of Special Attack 2 for other Synergy Members grant a Fury Buff for 6 seconds, increasing Attack by 15% of Base Attack which is doubled if all Champions of the Synergy are present.
Mister Fantastic activates 'H.E.R.B.I.E.' where Other Synergy Members heal 10% of Max Health over 6 seconds if at or below 20% health at the start of the fight, otherwise gain 60% of a Bar of Power over 6 seconds instead.
If all of the Fantastic Four are in the team the unique synergy is activated so that whenever Thing would gain a Rock Stack he gains an additional one and for Mister Fantatic with each unique Debuff on the Opponent they take 4% of Mister Fantastic’s current Attack Rating as Direct Damage per second.

Mister Fantastic

Mister Fantastic Synergy with Thing

Star Synergy Bonus
Mister Fantastic 3 Star H.E.R.B.I.E. See Notes
Mister Fantastic 4 Star H.E.R.B.I.E. + The Fantastic Four See Notes
Mister Fantastic 5 Star H.E.R.B.I.E. + The Fantastic Four See Notes
Mister Fantastic 6 Star H.E.R.B.I.E. + The Fantastic Four See Notes
Thing

Thing Synergy with Mister Fantastic

Star Synergy Bonus
Mister Fantastic 2 Star The Brave and the Boulder See Notes
Mister Fantastic 3 Star The Brave and the Boulder See Notes
Mister Fantastic 4 Star The Brave and the Boulder See Notes
Mister Fantastic 5 Star The Brave and the Boulder See Notes
Mister Fantastic 6 Star The Brave and the Boulder See Notes
Please note: Mister Fantastic can also activate 'H.E.R.B.I.E.' with Human Torch or Invisible Woman as an alternative. Mister Fantastic can also activate 'The Fantastic Four' with Human Torch or Invisible Woman as an alternative.
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Vulture

Adding Mister Fantastic with activates the 'Shared Knowledge - Robotics' synergy bonus where Tech and Science Champion’s Debuffs also apply an indefinite Power Sting, dealing Direct Damage equal to 60% of their Attack Rating when the Opponent activates a Special Attack. The Power Sting stacks up to 3 times. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Fantastic

Mister Fantastic Synergy with Vulture

Star Synergy Bonus
Mister Fantastic 3 Star Shared Knowledge - Robotics See Notes
Mister Fantastic 4 Star Shared Knowledge - Robotics See Notes
Mister Fantastic 5 Star Shared Knowledge - Robotics See Notes
Mister Fantastic 6 Star Shared Knowledge - Robotics See Notes
Please note: Mister Fantastic can also activate 'Shared Knowledge - Robotics' with Sentry, She-Hulk or Doctor Octopus as an alternative.
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