Symbiote Supreme Cover

Symbiote Supreme Synergy Guide

Symbiote Supreme is a Mystic class champion in the Contest of Champions who forms a synergy with 13 other characters, available as a 3-Star, 4-Star, 5-Star and 6-Star champion.

The result of an unholy union between an alternate reality Doctor Strange and a particularly virulent Klyntar specimen, the entity known as Symbiote Supreme wields an unnatural power thanks to its mastery of Symbiomancy: the ability to summon and control its Symbiote through magical means. The Symbiote Supreme finds and bonds with any lifeform it can, devouring them into its hivemind in order to spread its dark influence across The Battlerealm.

Synergy Bonuses

Synergy Partners

  • Agent VenomAgent Venom
  • CarnageCarnage
  • DiabloDiablo
  • Doctor DoomDoctor Doom
  • Doctor StrangeDoctor Strange
  • DormammuDormammu
  • MephistoMephisto
  • MordoMordo
  • Spider-GwenSpider-Gwen
  • Spider-Man (Symbiote)Spider-Man (Symbiote)
  • VenomVenom
  • Venom the DuckVenom the Duck
  • VenompoolVenompool
Symbiote Supreme


Agent Venom

Adding Symbiote Supreme with activates the 'Supreme Symbiosis' synergy bonus increasing the duration of all Bleed Debuff Effects for Symbiotes by 20% and for Symbiote Supreme each time a Stagger's Duration Expires, it has a 25% chance to re-apply itself. This is a Unique Synergy which does not stack with duplicate synergies.

Symbiote Supreme

Symbiote Supreme Synergy with Agent Venom

Star Synergy Bonus
Symbiote Supreme 4 Star Supreme Symbiosis See Notes
Symbiote Supreme 5 Star Supreme Symbiosis See Notes
Symbiote Supreme 6 Star Supreme Symbiosis See Notes
Please note: Symbiote Supreme can also activate 'Supreme Symbiosis' with Carnage, Spider-Man (Symbiote), Venom, Venom the Duck or Venompool as an alternative.

Carnage

Adding Symbiote Supreme with activates the 'Supreme Symbiosis' synergy bonus increasing the duration of all Bleed Debuff Effects for Symbiotes by 20% and for Symbiote Supreme each time a Stagger's Duration Expires, it has a 25% chance to re-apply itself. This is a Unique Synergy which does not stack with duplicate synergies.

Symbiote Supreme

Symbiote Supreme Synergy with Carnage

Star Synergy Bonus
Symbiote Supreme 4 Star Supreme Symbiosis See Notes
Symbiote Supreme 5 Star Supreme Symbiosis See Notes
Symbiote Supreme 6 Star Supreme Symbiosis See Notes
Please note: Symbiote Supreme can also activate 'Supreme Symbiosis' with Agent Venom, Spider-Man (Symbiote), Venom, Venom the Duck or Venompool as an alternative.

Diablo

Add to a team with Symbiote Supreme to activate the 'Twisted Arcanists' synergy bonus where Diablo gets to recover 1 Emberboon after winning 1 Fight and Symbiote Supreme gets +1% Attack per for each Stagger on the opponent. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Diablo

Diablo Synergy with Symbiote Supreme

Star Synergy Bonus
Symbiote Supreme 4 Star Twisted Arcanists See Notes
Symbiote Supreme 5 Star Twisted Arcanists See Notes
Symbiote Supreme 6 Star Twisted Arcanists See Notes

Doctor Doom

Add to a team with Symbiote Supreme to activate the 'Sorcery Reversal' synergy bonus so when Doctor Doom activates the Aura of Haazareth it has a 50% chance to Purify all Degeneration, Poison, Incinerate, Bleed and Cold Snap Debuffs. Please note this is a solo synergy which does not stack.

Doctor Doom

Doctor Doom Synergy with Symbiote Supreme

Star Synergy Bonus
Symbiote Supreme 4 Star Sorcery Reversal See Notes
Symbiote Supreme 5 Star Sorcery Reversal See Notes

Doctor Strange

Adding Symbiote Supreme with activates the 'Mystic Masters' synergy bonus where Symbiote Supreme gets to start the fight with 1 bar of Power and DR Strange deals 50% of Base Attack as Direct Damage when Nullifying a Buff off the Opponent. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Symbiote Supreme

Symbiote Supreme Synergy with Doctor Strange

Star Synergy Bonus
Symbiote Supreme 3 Star Mystic Masters See Notes
Symbiote Supreme 4 Star Mystic Masters See Notes
Symbiote Supreme 5 Star Mystic Masters See Notes
Symbiote Supreme 6 Star Mystic Masters See Notes
Please note: Symbiote Supreme can also activate 'Mystic Masters' with Mordo as an alternative.

Dormammu

Adding Symbiote Supreme with activates the 'Ancient Hunger' synergy bonus where the Special 2 effects for Symbiote Supreme trigger through block and Dormammu increases Health Regenerated by an Empowered Soul Bond by 50%. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Symbiote Supreme

Symbiote Supreme Synergy with Dormammu

Star Synergy Bonus
Symbiote Supreme 3 Star Ancient Hunger See Notes
Symbiote Supreme 4 Star Ancient Hunger See Notes
Symbiote Supreme 5 Star Ancient Hunger See Notes
Symbiote Supreme 6 Star Ancient Hunger See Notes
Please note: Symbiote Supreme can also activate 'Ancient Hunger' with Mephisto as an alternative.

Mephisto

Adding Symbiote Supreme with activates the 'Ancient Hunger' synergy bonus where the Special 2 effects for Symbiote Supreme trigger through block and Mephisto gets a 15% chance to trigger Aura of Incineration on Basic Attack Hits. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Symbiote Supreme

Symbiote Supreme Synergy with Mephisto

Star Synergy Bonus
Symbiote Supreme 3 Star Ancient Hunger See Notes
Symbiote Supreme 4 Star Ancient Hunger See Notes
Symbiote Supreme 5 Star Ancient Hunger See Notes
Symbiote Supreme 6 Star Ancient Hunger See Notes
Please note: Symbiote Supreme can also activate 'Ancient Hunger' with Dormammu as an alternative.

Mordo

Adding Symbiote Supreme with activates the 'Mystic Masters' synergy bonus where Symbiote Supreme gets to start the fight with 1 bar of Power and Mordo gains +15% of Base Attack as a Passive Attack bonus while the Opponent is under a Buff effect. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Symbiote Supreme

Symbiote Supreme Synergy with Mordo

Star Synergy Bonus
Symbiote Supreme 3 Star Mystic Masters See Notes
Symbiote Supreme 4 Star Mystic Masters See Notes
Symbiote Supreme 5 Star Mystic Masters See Notes
Symbiote Supreme 6 Star Mystic Masters See Notes
Please note: Symbiote Supreme can also activate 'Mystic Masters' with Doctor Strange as an alternative.

Spider-Gwen

Add to a team with Symbiote Supreme to activate the 'Gwenom Rising' synergy bonus where Spider-Sense charges for Spider-Gwen are evolved, reducing their evade chance by half. They also now grant an additional 10% Attack rating each and their max cap is raised by 1. This is a Solo synergy which does not stack.

Spider-Gwen

Spider-Gwen Synergy with Symbiote Supreme

Star Synergy Bonus
Symbiote Supreme 4 Star Gwenom Rising See Notes
Symbiote Supreme 5 Star Gwenom Rising See Notes

Spider-Man (Symbiote)

Adding Symbiote Supreme with activates the 'Supreme Symbiosis' synergy bonus increasing the duration of all Bleed Debuff Effects for Symbiotes by 20% and for Symbiote Supreme each time a Stagger's Duration Expires, it has a 25% chance to re-apply itself. This is a Unique Synergy which does not stack with duplicate synergies.

Symbiote Supreme

Symbiote Supreme Synergy with Spider-Man (Symbiote)

Star Synergy Bonus
Symbiote Supreme 4 Star Supreme Symbiosis See Notes
Symbiote Supreme 5 Star Supreme Symbiosis See Notes
Symbiote Supreme 6 Star Supreme Symbiosis See Notes
Please note: Symbiote Supreme can also activate 'Supreme Symbiosis' with Agent Venom, Carnage, Venom, Venom the Duck or Venompool as an alternative.

Venom

Adding Symbiote Supreme with activates the 'Supreme Symbiosis' synergy bonus increasing the duration of all Bleed Debuff Effects for Symbiotes by 20% and for Symbiote Supreme each time a Stagger's Duration Expires, it has a 25% chance to re-apply itself. This is a Unique Synergy which does not stack with duplicate synergies.

Symbiote Supreme

Symbiote Supreme Synergy with Venom

Star Synergy Bonus
Symbiote Supreme 4 Star Supreme Symbiosis See Notes
Symbiote Supreme 5 Star Supreme Symbiosis See Notes
Symbiote Supreme 6 Star Supreme Symbiosis See Notes
Please note: Symbiote Supreme can also activate 'Supreme Symbiosis' with Agent Venom, Carnage, Spider-Man (Symbiote), Venom the Duck or Venompool as an alternative.

Venom the Duck

Team Symbiote Supreme with to create a perfect synergy, with each champion activating their own bonus depending on their star-rating. Symbiote Supreme activates the 'Supreme Symbiosis' synergy bonus increasing the duration of all Bleed Debuff Effects by 20% for all Symbiotes on the team, and for Symbiote Supreme each time a Stagger's Duration Expires it has a 25% chance to re-apply itself. Venom the Duck adds the 'Genetic Recode - Barrier' bonus, which gives Venom the Duck +15% Nullify & Fate Seal Resistance. Please note these do not stack with duplicate synergies.

Symbiote Supreme

Symbiote Supreme Synergy with Venom the Duck

Star Synergy Bonus
Symbiote Supreme 4 Star Supreme Symbiosis See Notes
Symbiote Supreme 5 Star Supreme Symbiosis See Notes
Symbiote Supreme 6 Star Supreme Symbiosis See Notes
Venom the Duck

Venom the Duck Synergy with Symbiote Supreme

Star Synergy Bonus
Symbiote Supreme 4 Star Genetic Recode - Barrier See Notes
Symbiote Supreme 5 Star Genetic Recode - Barrier See Notes
Symbiote Supreme 6 Star Genetic Recode - Barrier See Notes
Please note: Symbiote Supreme can also activate 'Supreme Symbiosis' with Agent Venom, Carnage, Spider-Man (Symbiote), Venom or Venompool as an alternative.

Venompool

Adding Symbiote Supreme with activates the 'Supreme Symbiosis' synergy bonus increasing the duration of all Bleed Debuff Effects for Symbiotes by 20% and for Symbiote Supreme each time a Stagger's Duration Expires, it has a 25% chance to re-apply itself. This is a Unique Synergy which does not stack with duplicate synergies.

Symbiote Supreme

Symbiote Supreme Synergy with Venompool

Star Synergy Bonus
Symbiote Supreme 4 Star Supreme Symbiosis See Notes
Symbiote Supreme 5 Star Supreme Symbiosis See Notes
Symbiote Supreme 6 Star Supreme Symbiosis See Notes
Please note: Symbiote Supreme can also activate 'Supreme Symbiosis' with Agent Venom, Carnage, Spider-Man (Symbiote), Venom or Venom the Duck as an alternative.