
Mephisto Synergy Guide
Mephisto is a Mystic class champion in the Contest of Champions who forms a synergy with 15 other characters, available as a 3-Star, 4-Star and 5-Star champion.
Mephisto is an extra-dimensional demon whose main goal is to break the will and enslave the souls of noble Champions; though he cannot take their souls himself, his treachery and deception often enough to convince his victims to give them up willingly. Mephisto is continually seeking to add more spirits to his realm, using them to his advantage whenever he sees fit. As a demon who has collected numerous souls, Mephisto is practically immortal and his fiery power is eternal.
Synergy Bonuses
- 'Demons' with Dormammu
- 'Soul Seeker' with Morningstar
- 'Pact with a Demon' with Doctor Strange or Ghost Rider

Black Widow (Claire Voyant)
Add Black Widow (Claire Voyant) to a team with Mephisto to activate the 'Fire and Forget' synergy bonus so that whenever the Opponent of Black Widow (Claire Voyant) or Mephisto is immune to Incinerate they’re inflicted with a Slow Debeuff for 8 seconds reducing the Ability Accuracy of Unstoppable and Evade effects by 100%. This Debuff does not stack and will not trigger if the Opponent has natural Class advantage. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Black Widow (Claire Voyant) Synergy with Mephisto
Star | Synergy | Bonus |
---|---|---|
Mephisto 4 Star | Fire and Forget | See Notes |
Mephisto 5 Star | Fire and Forget | See Notes |
Blade
Add Blade to a team with Mephisto to activate the 'Demon Hunter' synergy bonus where Mephisto reduces their opponent's Energy Resistance by 30% and Blade expands his Danger Sense bonuses to include all Mystic Champions. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Blade Synergy with Mephisto
Star | Synergy | Bonus |
---|---|---|
Mephisto 2 Star | Demon Hunter | See Notes |
Mephisto 3 Star | Demon Hunter | See Notes |
Mephisto 4 Star | Demon Hunter | See Notes |
Mephisto 5 Star | Demon Hunter | See Notes |
Diablo
Add Diablo to a team with Mephisto to activate the 'Legion Accursed' synergy bonus where Diablo gets to recover 1 Ironskin after winning 1 Fight and Mephisto gains 40% of a Power bar when a Poison Debuff would be gained. Cooldown 10 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Diablo Synergy with Mephisto
Star | Synergy | Bonus |
---|---|---|
Mephisto 4 Star | Legion Accursed | See Notes |
Mephisto 5 Star | Legion Accursed | See Notes |
Mephisto 6 Star | Legion Accursed | See Notes |
Doctor Strange
Adding Mephisto with Doctor Strange activates the 'Pact with a Demon' synergy bonus where Mephisto gets +70% Incinerate Energy Damage and Doctor Strange heals an additional 70% with Life Steal. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mephisto Synergy with Doctor Strange
Star | Synergy | Bonus |
---|---|---|
Mephisto 3 Star | Pact with a Demon | See Notes |
Mephisto 4 Star | Pact with a Demon | See Notes |
Mephisto 5 Star | Pact with a Demon | See Notes |
Dormammu
Adding Mephisto with Dormammu activates the 'Demons' synergy bonus where both Mephisto and Dormammu gain +80% Energy Resistance while they are taking Damage over time. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mephisto Synergy with Dormammu
Star | Synergy | Bonus |
---|---|---|
Mephisto 3 Star | Demons | See Notes |
Mephisto 4 Star | Demons | See Notes |
Mephisto 5 Star | Demons | See Notes |
Ghost Rider
Adding Mephisto with Ghost Rider activates the 'Pact with a Demon' synergy bonus where Mephisto gets +70% Incinerate Energy Damage whilst Ghost Rider gets +10% Attack at the start of the fight. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mephisto Synergy with Ghost Rider
Star | Synergy | Bonus |
---|---|---|
Mephisto 3 Star | Pact with a Demon | See Notes |
Mephisto 4 Star | Pact with a Demon | See Notes |
Mephisto 5 Star | Pact with a Demon | See Notes |
Guillotine 2099
Add Guillotine 2099 to a team with Mephisto to activate the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Guillotine 2099 Synergy with Mephisto
Star | Synergy | Bonus |
---|---|---|
Mephisto 3 Star | Nemesis Level 2 | +5% Attack |
Mephisto 4 Star | Nemesis Level 3 | +6% Attack |
Mephisto 5 Star | Nemesis Level 3 | +6% Attack |
Mephisto 6 Star | Nemesis Level 3 | +6% Attack |
Hela
Add Hela to a team with Mephisto to activate the 'Hell Lords' synergy bonus where Mephisto regains the first Soul spent to trigger his Soul Imprisonment each fight and Hela gets to begin the fight with 1 bar of Power. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Hela Synergy with Mephisto
Star | Synergy | Bonus |
---|---|---|
Mephisto 3 Star | Hell Lords | See Notes |
Mephisto 4 Star | Hell Lords | See Notes |
Mephisto 5 Star | Hell Lords | See Notes |
Mephisto 6 Star | Hell Lords | See Notes |
Morningstar
Adding Mephisto with Morningstar activates the 'Soul Seeker' synergy bonus where Morningstar gets to start the fight with 1 bar of Power and Mephisto gains +1 Soul at the beginning of the fight. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mephisto Synergy with Morningstar
Star | Synergy | Bonus |
---|---|---|
Mephisto 4 Star | Soul Seeker | See Notes |
Mephisto 5 Star | Soul Seeker | See Notes |
Omega Red
Add Omega Red to a team with Mephisto to activate the 'Deadly Presence' synergy bonus where Death Field for Omega Red deals 10% more damage while Aura of Incineration for Mephisto deals 15% more damage. This is a Unique Synergy which does not stack with duplicate synergies.

Omega Red Synergy with Mephisto
Star | Synergy | Bonus |
---|---|---|
Mephisto 4 Star | Deadly Presence | See Notes |
Mephisto 5 Star | Deadly Presence | See Notes |
Mephisto 6 Star | Deadly Presence | See Notes |
She-Hulk
Add She-Hulk to a team with Mephisto to activate the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

She-Hulk Synergy with Mephisto
Star | Synergy | Bonus |
---|---|---|
Mephisto 4 Star | Enemies Level 3 | +155 Critical Rating |
Mephisto 5 Star | Enemies Level 3 | +155 Critical Rating |
Silver Surfer
Add Silver Surfer to a team with Mephisto to activate the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Silver Surfer Synergy with Mephisto
Star | Synergy | Bonus |
---|---|---|
Mephisto 3 Star | Enemies Level 1 | +85 Critical Rating |
Mephisto 4 Star | Enemies Level 2 | +115 Critical Rating |
Mephisto 5 Star | Enemies Level 3 | +155 Critical Rating |
Sunspot
Add Sunspot to a team with Mephisto to activate the 'Enemies Lv. 3' synergy bonus where all Champions gain +125 Critical Rating which is increased up to +325 based on Sunspot's Signature Level.

Sunspot Synergy with Mephisto
Star | Synergy | Bonus |
---|---|---|
Mephisto 3 Star | Enemies Lv. 3 | +125 Critical Rating |
Mephisto 4 Star | Enemies Lv. 3 | +125 Critical Rating |
Mephisto 5 Star | Enemies Lv. 3 | +125 Critical Rating |
Mephisto 6 Star | Enemies Lv. 3 | +125 Critical Rating |
Symbiote Supreme
Add Symbiote Supreme to a team with Mephisto to activate the 'Ancient Hunger' synergy bonus where the Special 2 effects for Symbiote Supreme trigger through block and Mephisto gets a 15% chance to trigger Aura of Incineration on Basic Attack Hits. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Symbiote Supreme Synergy with Mephisto
Star | Synergy | Bonus |
---|---|---|
Mephisto 3 Star | Ancient Hunger | See Notes |
Mephisto 4 Star | Ancient Hunger | See Notes |
Mephisto 5 Star | Ancient Hunger | See Notes |
Mephisto 6 Star | Ancient Hunger | See Notes |
The Champion
Add The Champion to a team with Mephisto to activate the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team. In addition The Champion activates the unique synergy 'Persistent Force' where he gets to start the fight with an Indestructible Buff if he has 3 or more Persistent Charges which ignores all incoming damage for 8 seconds. Mephisto gets +15% Attack Rating for each Persistent Charge.

The Champion Synergy with Mephisto
Star | Synergy | Bonus |
---|---|---|
Mephisto 3 Star | Persistent Force + Enemies Level 2 | See Notes + +115 Critical Rating |
Mephisto 4 Star | Persistent Force + Enemies Level 3 | See Notes + +155 Critical Rating |
Mephisto 5 Star | Persistent Force + Enemies Level 3 | See Notes + +155 Critical Rating |
Mephisto 6 Star | Persistent Force + Enemies Level 3 | See Notes + +155 Critical Rating |