Mephisto Cover

Mephisto Synergy Guide

Mephisto is a Mystic class champion in the Contest of Champions who forms a synergy with 14 other characters, available as a 3-Star, 4-Star and 5-Star champion.

Mephisto is an extra-dimensional demon whose main goal is to break the will and enslave the souls of noble Champions; though he cannot take their souls himself, his treachery and deception often enough to convince his victims to give them up willingly. Mephisto is continually seeking to add more spirits to his realm, using them to his advantage whenever he sees fit. As a demon who has collected numerous souls, Mephisto is practically immortal and his fiery power is eternal.

Synergy Bonuses

Synergy Partners

  • Black Widow (Claire Voyant)Black Widow (Claire Voyant)
  • BladeBlade
  • DiabloDiablo
  • Doctor StrangeDoctor Strange
  • DormammuDormammu
  • Ghost RiderGhost Rider
  • Guillotine 2099Guillotine 2099
  • HelaHela
  • MorningstarMorningstar
  • Omega RedOmega Red
  • She-HulkShe-Hulk
  • SunspotSunspot
  • Symbiote SupremeSymbiote Supreme
  • The ChampionThe Champion
Mephisto


Black Widow (Claire Voyant)

Add to a team with Mephisto to activate the 'Fire and Forget' synergy bonus so that whenever the Opponent of Black Widow (Claire Voyant) or Mephisto is immune to Incinerate they’re inflicted with a Slow Debeuff for 8 seconds reducing the Ability Accuracy of Unstoppable and Evade effects by 100%. This Debuff does not stack and will not trigger if the Opponent has natural Class advantage. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Black Widow (Claire Voyant)

Black Widow (Claire Voyant) Synergy with Mephisto

Star Synergy Bonus
Mephisto 4 Star Fire and Forget See Notes
Mephisto 5 Star Fire and Forget See Notes

Blade

Add to a team with Mephisto to activate the 'Demon Hunter' synergy bonus where Mephisto reduces their opponent's Energy Resistance by 30% and Blade expands his Danger Sense bonuses to include all Mystic Champions. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Blade

Blade Synergy with Mephisto

Star Synergy Bonus
Mephisto 2 Star Demon Hunter See Notes
Mephisto 3 Star Demon Hunter See Notes
Mephisto 4 Star Demon Hunter See Notes
Mephisto 5 Star Demon Hunter See Notes

Diablo

Add to a team with Mephisto to activate the 'Legion Accursed' synergy bonus where Diablo gets to recover 1 Ironskin after winning 1 Fight and Mephisto gains 40% of a Power bar when a Poison Debuff would be gained. Cooldown 10 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Diablo

Diablo Synergy with Mephisto

Star Synergy Bonus
Mephisto 4 Star Legion Accursed See Notes
Mephisto 5 Star Legion Accursed See Notes
Mephisto 6 Star Legion Accursed See Notes

Doctor Strange

Adding Mephisto with activates the 'Pact with a Demon' synergy bonus where Mephisto gets +70% Incinerate Energy Damage and Doctor Strange heals an additional 70% with Life Steal. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mephisto

Mephisto Synergy with Doctor Strange

Star Synergy Bonus
Mephisto 3 Star Pact with a Demon See Notes
Mephisto 4 Star Pact with a Demon See Notes
Mephisto 5 Star Pact with a Demon See Notes
Please note: Mephisto can also activate 'Pact with a Demon' with Ghost Rider as an alternative.

Dormammu

Adding Mephisto with activates the 'Demons' synergy bonus where both Mephisto and Dormammu gain +80% Energy Resistance while they are taking Damage over time. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mephisto

Mephisto Synergy with Dormammu

Star Synergy Bonus
Mephisto 3 Star Demons See Notes
Mephisto 4 Star Demons See Notes
Mephisto 5 Star Demons See Notes

Ghost Rider

Adding Mephisto with activates the 'Pact with a Demon' synergy bonus where Mephisto gets +70% Incinerate Energy Damage whilst Ghost Rider gets +10% Attack at the start of the fight. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mephisto

Mephisto Synergy with Ghost Rider

Star Synergy Bonus
Mephisto 3 Star Pact with a Demon See Notes
Mephisto 4 Star Pact with a Demon See Notes
Mephisto 5 Star Pact with a Demon See Notes
Please note: Mephisto can also activate 'Pact with a Demon' with Doctor Strange as an alternative.

Guillotine 2099

Add to a team with Mephisto to activate the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Guillotine 2099

Guillotine 2099 Synergy with Mephisto

Star Synergy Bonus
Mephisto 3 Star Nemesis Level 2 +5% Attack
Mephisto 4 Star Nemesis Level 3 +6% Attack
Mephisto 5 Star Nemesis Level 3 +6% Attack
Mephisto 6 Star Nemesis Level 3 +6% Attack

Hela

Add to a team with Mephisto to activate the 'Hell Lords' synergy bonus where Mephisto regains the first Soul spent to trigger his Soul Imprisonment each fight and Hela gets to begin the fight with 1 bar of Power. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Hela

Hela Synergy with Mephisto

Star Synergy Bonus
Mephisto 3 Star Hell Lords See Notes
Mephisto 4 Star Hell Lords See Notes
Mephisto 5 Star Hell Lords See Notes
Mephisto 6 Star Hell Lords See Notes

Morningstar

Adding Mephisto with activates the 'Soul Seeker' synergy bonus where Morningstar gets to start the fight with 1 bar of Power and Mephisto gains +1 Soul at the beginning of the fight. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mephisto

Mephisto Synergy with Morningstar

Star Synergy Bonus
Mephisto 4 Star Soul Seeker See Notes
Mephisto 5 Star Soul Seeker See Notes

Omega Red

Add to a team with Mephisto to activate the 'Deadly Presence' synergy bonus where Death Field for Omega Red deals 10% more damage while Aura of Incineration for Mephisto deals 15% more damage. This is a Unique Synergy which does not stack with duplicate synergies.

Omega Red

Omega Red Synergy with Mephisto

Star Synergy Bonus
Mephisto 4 Star Deadly Presence See Notes
Mephisto 5 Star Deadly Presence See Notes
Mephisto 6 Star Deadly Presence See Notes

She-Hulk

Add to a team with Mephisto to activate the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

She-Hulk

She-Hulk Synergy with Mephisto

Star Synergy Bonus
Mephisto 4 Star Enemies Level 3 +155 Critical Rating
Mephisto 5 Star Enemies Level 3 +155 Critical Rating

Sunspot

Add to a team with Mephisto to activate the 'Enemies Lv. 3' synergy bonus where all Champions gain +125 Critical Rating which is increased up to +325 based on Sunspot's Signature Level.

Sunspot

Sunspot Synergy with Mephisto

Star Synergy Bonus
Mephisto 3 Star Enemies Lv. 3 +125 Critical Rating
Mephisto 4 Star Enemies Lv. 3 +125 Critical Rating
Mephisto 5 Star Enemies Lv. 3 +125 Critical Rating
Mephisto 6 Star Enemies Lv. 3 +125 Critical Rating

Symbiote Supreme

Add to a team with Mephisto to activate the 'Ancient Hunger' synergy bonus where the Special 2 effects for Symbiote Supreme trigger through block and Mephisto gets a 15% chance to trigger Aura of Incineration on Basic Attack Hits. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Symbiote Supreme

Symbiote Supreme Synergy with Mephisto

Star Synergy Bonus
Mephisto 3 Star Ancient Hunger See Notes
Mephisto 4 Star Ancient Hunger See Notes
Mephisto 5 Star Ancient Hunger See Notes
Mephisto 6 Star Ancient Hunger See Notes

The Champion

Add to a team with Mephisto to activate the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team. In addition The Champion activates the unique synergy 'Persistent Force' where he gets to start the fight with an Indestructible Buff if he has 3 or more Persistent Charges which ignores all incoming damage for 8 seconds. Mephisto gets +15% Attack Rating for each Persistent Charge.

The Champion

The Champion Synergy with Mephisto

Star Synergy Bonus
Mephisto 3 Star Persistent Force + Enemies Level 2 See Notes + +115 Critical Rating
Mephisto 4 Star Persistent Force + Enemies Level 3 See Notes + +155 Critical Rating
Mephisto 5 Star Persistent Force + Enemies Level 3 See Notes + +155 Critical Rating
Mephisto 6 Star Persistent Force + Enemies Level 3 See Notes + +155 Critical Rating