
Mister Sinister Synergy Guide
Mister Sinister is a Mutant class champion in the Contest of Champions who forms a synergy with 11 other characters, available as a 3-Star, 4-Star, 5-Star and 6-Star champion.
Nathaniel Essex, a scientist in the latter half of the 19th century, pledged loyalty to the mutant-demi god Apocalypse in exchange for activation of his dormant X-Factor. Donning the moniker of Mister Sinister, Essex began to engineer bloodlines in the hope of creating the perfect mutant. His attention would eventually focus on two particularly gifted children, Scott Summers and Jean Grey. In command of the Marauders, a band of mutants that follow him, Mister Sinister has been the mastermind of many schemes and plots, not the least of which was the birth of Cyclops and Madelyne Pryor's child, Nathan Summers, also known as Cable.
Synergy Bonuses
- 'Blood Lines' with Cyclops (Blue Team), Cyclops (New Xavier School) or Phoenix
- 'Genetic Masterpiece' with Cable
- 'Mutant Domination' with Magneto or Magneto (Marvel Now)
- 'Masterminds' with Kingpin, M.O.D.O.K. or Ultron

Cable
Adding Mister Sinister with Cable activates the 'Genetic Masterpiece' synergy bonus where All Mutants randomly start the fight with either +25% passive Attack Rating, +25% passive Power Rate, or +25% passive Armor Rating. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister Synergy with Cable
Star | Synergy | Bonus |
---|---|---|
Mister Sinister 3 Star | Genetic Masterpiece | See Notes |
Mister Sinister 4 Star | Genetic Masterpiece | See Notes |
Mister Sinister 5 Star | Genetic Masterpiece | See Notes |
Mister Sinister 6 Star | Genetic Masterpiece | See Notes |
Colossus
Add Colossus to a team with Mister Sinister to activate the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Colossus Synergy with Mister Sinister
Star | Synergy | Bonus |
---|---|---|
Mister Sinister 2 Star | Enemies Level 1 | +85 Critical Rating |
Mister Sinister 3 Star | Enemies Level 2 | +115 Critical Rating |
Mister Sinister 4 Star | Enemies Level 3 | +155 Critical Rating |
Mister Sinister 5 Star | Enemies Level 3 | +155 Critical Rating |
Cyclops (Blue Team)
Adding Mister Sinister with Cyclops (Blue Team) activates the 'Blood Lines' synergy bonus where Special Attacks for Cyclops (Blue Team) and Mister Sinister have 20% Critical Rating and gain True Strike, ignoring all Armor, Resistances, Evasion and Auto Block. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister Synergy with Cyclops (Blue Team)
Star | Synergy | Bonus |
---|---|---|
Mister Sinister 3 Star | Blood Lines | See Notes |
Mister Sinister 4 Star | Blood Lines | See Notes |
Mister Sinister 5 Star | Blood Lines | See Notes |
Mister Sinister 6 Star | Blood Lines | See Notes |
Cyclops (New Xavier School)
Adding Mister Sinister with Cyclops (New Xavier School) activates the 'Blood Lines' synergy bonus where Special Attacks for Cyclops (New Xavier School) and Mister Sinister have 20% Critical Rating and gain True Strike, ignoring all Armor, Resistances, Evasion and Auto Block. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister Synergy with Cyclops (New Xavier School)
Star | Synergy | Bonus |
---|---|---|
Mister Sinister 3 Star | Blood Lines | See Notes |
Mister Sinister 4 Star | Blood Lines | See Notes |
Mister Sinister 5 Star | Blood Lines | See Notes |
Mister Sinister 6 Star | Blood Lines | See Notes |
Havok
Add Havok to a team with Mister Sinister to activate the 'Runs in the Family' synergy bonus where Havok gains 2 Plasma Charges after each Special Attack and Well Timed Blocks against contact attacks for Mister Sinister inflict Degeneration, dealing 30% of Attack as Direct Damage overs 1 second. Cooldown 10 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Havok Synergy with Mister Sinister
Star | Synergy | Bonus |
---|---|---|
Mister Sinister 3 Star | Runs in the Family | See Notes |
Mister Sinister 4 Star | Runs in the Family | See Notes |
Mister Sinister 5 Star | Runs in the Family | See Notes |
Mister Sinister 6 Star | Runs in the Family | See Notes |
Kingpin
Adding Mister Sinister with Kingpin activates the 'Masterminds' synergy bonus where each time the opponent uses a Special Attack against Kingpin or Mister Sinister they become Power Locked for 6 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister Synergy with Kingpin
Star | Synergy | Bonus |
---|---|---|
Mister Sinister 4 Star | Masterminds | See Notes |
Mister Sinister 5 Star | Masterminds | See Notes |
Mister Sinister 6 Star | Masterminds | See Notes |
M.O.D.O.K.
Adding Mister Sinister with M.O.D.O.K. activates the 'Masterminds' synergy bonus where each time the opponent uses a Special Attack against M.O.D.O.K. or Mister Sinister they become Power Locked for 6 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister Synergy with M.O.D.O.K.
Star | Synergy | Bonus |
---|---|---|
Mister Sinister 4 Star | Masterminds | See Notes |
Mister Sinister 5 Star | Masterminds | See Notes |
Mister Sinister 6 Star | Masterminds | See Notes |
Magneto
Adding Mister Sinister with Magneto activates the 'Mutant Domination' synergy bonus where All Mutants gain +20% Passive Fury when fighting with Class Disadvantage. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister Synergy with Magneto
Star | Synergy | Bonus |
---|---|---|
Mister Sinister 3 Star | Mutant Domination | See Notes |
Mister Sinister 4 Star | Mutant Domination | See Notes |
Mister Sinister 5 Star | Mutant Domination | See Notes |
Mister Sinister 6 Star | Mutant Domination | See Notes |
Magneto (Marvel Now)
Adding Mister Sinister with Magneto (Marvel Now) activates the 'Mutant Domination' synergy bonus where All Mutants gain +20% Passive Fury when fighting with Class Disadvantage. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister Synergy with Magneto (Marvel Now)
Star | Synergy | Bonus |
---|---|---|
Mister Sinister 3 Star | Mutant Domination | See Notes |
Mister Sinister 4 Star | Mutant Domination | See Notes |
Mister Sinister 5 Star | Mutant Domination | See Notes |
Mister Sinister 6 Star | Mutant Domination | See Notes |
Phoenix
Adding Mister Sinister with Phoenix activates the 'Blood Lines' synergy bonus where Special Attacks for Phoenix and Mister Sinister have 20% Critical Rating and gain True Strike, ignoring all Armor, Resistances, Evasion and Auto Block. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister Synergy with Phoenix
Star | Synergy | Bonus |
---|---|---|
Mister Sinister 3 Star | Blood Lines | See Notes |
Mister Sinister 4 Star | Blood Lines | See Notes |
Mister Sinister 5 Star | Blood Lines | See Notes |
Mister Sinister 6 Star | Blood Lines | See Notes |
Ultron
Adding Mister Sinister with Ultron activates the 'Masterminds' synergy bonus where each time the opponent uses a Special Attack against Ultron or Mister Sinister they become Power Locked for 6 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister Synergy with Ultron
Star | Synergy | Bonus |
---|---|---|
Mister Sinister 4 Star | Masterminds | See Notes |
Mister Sinister 5 Star | Masterminds | See Notes |
Mister Sinister 6 Star | Masterminds | See Notes |