Mister Sinister Cover

Mister Sinister Synergy Guide

Mister Sinister is a Mutant class champion in the Contest of Champions who forms a synergy with 11 other characters, available as a 3-Star, 4-Star, 5-Star and 6-Star champion.

Nathaniel Essex, a scientist in the latter half of the 19th century, pledged loyalty to the mutant-demi god Apocalypse in exchange for activation of his dormant X-Factor. Donning the moniker of Mister Sinister, Essex began to engineer bloodlines in the hope of creating the perfect mutant. His attention would eventually focus on two particularly gifted children, Scott Summers and Jean Grey. In command of the Marauders, a band of mutants that follow him, Mister Sinister has been the mastermind of many schemes and plots, not the least of which was the birth of Cyclops and Madelyne Pryor's child, Nathan Summers, also known as Cable.

Synergy Bonuses

Synergy Partners

  • CableCable
  • ColossusColossus
  • Cyclops (Blue Team)Cyclops (Blue Team)
  • Cyclops (New Xavier School)Cyclops (New Xavier School)
  • HavokHavok
  • KingpinKingpin
  • M.O.D.O.K.M.O.D.O.K.
  • MagnetoMagneto
  • Magneto (Marvel Now)Magneto (Marvel Now)
  • PhoenixPhoenix
  • UltronUltron
Mister Sinister


Cable

Adding Mister Sinister with activates the 'Genetic Masterpiece' synergy bonus where All Mutants randomly start the fight with either +25% passive Attack Rating, +25% passive Power Rate, or +25% passive Armor Rating. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister

Mister Sinister Synergy with Cable

Star Synergy Bonus
Mister Sinister 3 Star Genetic Masterpiece See Notes
Mister Sinister 4 Star Genetic Masterpiece See Notes
Mister Sinister 5 Star Genetic Masterpiece See Notes
Mister Sinister 6 Star Genetic Masterpiece See Notes
Please note: The 'Genetic Masterpiece' synergy bonus is only beneficial for the other Mutant champions in your team.

Colossus

Add to a team with Mister Sinister to activate the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Colossus

Colossus Synergy with Mister Sinister

Star Synergy Bonus
Mister Sinister 2 Star Enemies Level 1 +85 Critical Rating
Mister Sinister 3 Star Enemies Level 2 +115 Critical Rating
Mister Sinister 4 Star Enemies Level 3 +155 Critical Rating
Mister Sinister 5 Star Enemies Level 3 +155 Critical Rating

Cyclops (Blue Team)

Adding Mister Sinister with activates the 'Blood Lines' synergy bonus where Special Attacks for Cyclops (Blue Team) and Mister Sinister have 20% Critical Rating and gain True Strike, ignoring all Armor, Resistances, Evasion and Auto Block. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister

Mister Sinister Synergy with Cyclops (Blue Team)

Star Synergy Bonus
Mister Sinister 3 Star Blood Lines See Notes
Mister Sinister 4 Star Blood Lines See Notes
Mister Sinister 5 Star Blood Lines See Notes
Mister Sinister 6 Star Blood Lines See Notes
Please note: Mister Sinister can also activate 'Blood Lines' with Cyclops (New Xavier School) or Phoenix as an alternative.

Cyclops (New Xavier School)

Adding Mister Sinister with activates the 'Blood Lines' synergy bonus where Special Attacks for Cyclops (New Xavier School) and Mister Sinister have 20% Critical Rating and gain True Strike, ignoring all Armor, Resistances, Evasion and Auto Block. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister

Mister Sinister Synergy with Cyclops (New Xavier School)

Star Synergy Bonus
Mister Sinister 3 Star Blood Lines See Notes
Mister Sinister 4 Star Blood Lines See Notes
Mister Sinister 5 Star Blood Lines See Notes
Mister Sinister 6 Star Blood Lines See Notes
Please note: Mister Sinister can also activate 'Blood Lines' with Cyclops (Blue Team) or Phoenix as an alternative.

Havok

Add to a team with Mister Sinister to activate the 'Runs in the Family' synergy bonus where Havok gains 2 Plasma Charges after each Special Attack and Well Timed Blocks against contact attacks for Mister Sinister inflict Degeneration, dealing 30% of Attack as Direct Damage overs 1 second. Cooldown 10 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Havok

Havok Synergy with Mister Sinister

Star Synergy Bonus
Mister Sinister 3 Star Runs in the Family See Notes
Mister Sinister 4 Star Runs in the Family See Notes
Mister Sinister 5 Star Runs in the Family See Notes
Mister Sinister 6 Star Runs in the Family See Notes

Kingpin

Adding Mister Sinister with activates the 'Masterminds' synergy bonus where each time the opponent uses a Special Attack against Kingpin or Mister Sinister they become Power Locked for 6 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister

Mister Sinister Synergy with Kingpin

Star Synergy Bonus
Mister Sinister 4 Star Masterminds See Notes
Mister Sinister 5 Star Masterminds See Notes
Mister Sinister 6 Star Masterminds See Notes
Please note: Mister Sinister can also activate 'Masterminds' with M.O.D.O.K. or Ultron as an alternative.

M.O.D.O.K.

Adding Mister Sinister with activates the 'Masterminds' synergy bonus where each time the opponent uses a Special Attack against M.O.D.O.K. or Mister Sinister they become Power Locked for 6 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister

Mister Sinister Synergy with M.O.D.O.K.

Star Synergy Bonus
Mister Sinister 4 Star Masterminds See Notes
Mister Sinister 5 Star Masterminds See Notes
Mister Sinister 6 Star Masterminds See Notes
Please note: Mister Sinister can also activate 'Masterminds' with Kingpin or Ultron as an alternative.

Magneto

Adding Mister Sinister with activates the 'Mutant Domination' synergy bonus where All Mutants gain +20% Passive Fury when fighting with Class Disadvantage. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister

Mister Sinister Synergy with Magneto

Star Synergy Bonus
Mister Sinister 3 Star Mutant Domination See Notes
Mister Sinister 4 Star Mutant Domination See Notes
Mister Sinister 5 Star Mutant Domination See Notes
Mister Sinister 6 Star Mutant Domination See Notes
Please note: The 'Mutant Domination' synergy bonus is only beneficial for the other Mutant champions in your team. Mister Sinister can also activate 'Mutant Domination' with Magneto (Marvel Now) as an alternative.

Magneto (Marvel Now)

Adding Mister Sinister with activates the 'Mutant Domination' synergy bonus where All Mutants gain +20% Passive Fury when fighting with Class Disadvantage. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister

Mister Sinister Synergy with Magneto (Marvel Now)

Star Synergy Bonus
Mister Sinister 3 Star Mutant Domination See Notes
Mister Sinister 4 Star Mutant Domination See Notes
Mister Sinister 5 Star Mutant Domination See Notes
Mister Sinister 6 Star Mutant Domination See Notes
Please note: The 'Mutant Domination' synergy bonus is only beneficial for the other Mutant champions in your team. Mister Sinister can also activate 'Mutant Domination' with Magneto as an alternative.

Phoenix

Adding Mister Sinister with activates the 'Blood Lines' synergy bonus where Special Attacks for Phoenix and Mister Sinister have 20% Critical Rating and gain True Strike, ignoring all Armor, Resistances, Evasion and Auto Block. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister

Mister Sinister Synergy with Phoenix

Star Synergy Bonus
Mister Sinister 3 Star Blood Lines See Notes
Mister Sinister 4 Star Blood Lines See Notes
Mister Sinister 5 Star Blood Lines See Notes
Mister Sinister 6 Star Blood Lines See Notes
Please note: Mister Sinister can also activate 'Blood Lines' with Cyclops (Blue Team) or Cyclops (New Xavier School) as an alternative.

Ultron

Adding Mister Sinister with activates the 'Masterminds' synergy bonus where each time the opponent uses a Special Attack against Ultron or Mister Sinister they become Power Locked for 6 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mister Sinister

Mister Sinister Synergy with Ultron

Star Synergy Bonus
Mister Sinister 4 Star Masterminds See Notes
Mister Sinister 5 Star Masterminds See Notes
Mister Sinister 6 Star Masterminds See Notes
Please note: Mister Sinister can also activate 'Masterminds' with Kingpin or M.O.D.O.K. as an alternative.