
Squirrel Girl Synergy Guide
Squirrel Girl is a Skill class champion in the Contest of Champions who forms a synergy with 10 other characters, available as a 3-Star, 4-Star, 5-Star and 6-Star champion.
Doreen Green's squirrel-like abilities made her an outsider in her teenage years. She escaped the insults of her classmates by hiding in the woods, among the squirrels. When Doreen stumbled upon Iron Man, she saw her chance to impress him, overpowering Doctor Doom with the help of her army of squirrels. Ever since her first victory, Squirrel Girl has taken down some of the most feared Super Villains in the universe. With an almost unrivalled win record, she lives up to the title, the "Unbeatable Squirrel Girl".
Synergy Bonuses
- 'Supernanny' with Luke Cage
- 'Deadpool's Guide to Super Villains' with Deadpool
- 'Hardwired for Heartbreak' with Sentinel
- 'Beat Up the Universe' with Doctor Doom, M.O.D.O.K., Thanos or Mordo

Deadpool
Adding Squirrel Girl with Deadpool activates the 'Deadpool's Guide to Super Villains' synergy bonus where Squirrel Girl reads Deadpool's Guide to Super Villains cards to gain an advantage which increases her Attack Rating by 10% while fighting Villain Champions. Please note this is a Solo Synergy which only affects this Champion and does not stack.

Squirrel Girl Synergy with Deadpool
Star | Synergy | Bonus |
---|---|---|
Squirrel Girl 3 Star | Deadpool's Guide to Super Villains | See Notes |
Squirrel Girl 4 Star | Deadpool's Guide to Super Villains | See Notes |
Squirrel Girl 5 Star | Deadpool's Guide to Super Villains | See Notes |
Squirrel Girl 6 Star | Deadpool's Guide to Super Villains | See Notes |
Doctor Doom
Adding Squirrel Girl with Doctor Doom activates the 'Beat Up the Universe' synergy bonus so that once per fight when Tippy Toe would Purify all non-damaging Debuffs on Squirrel Girl it will also Purify 1 damaging Debuff and Aura of Haazareth for Doctor Doom lasts an additional 2 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Squirrel Girl Synergy with Doctor Doom
Star | Synergy | Bonus |
---|---|---|
Squirrel Girl 5 Star | Beat Up the Universe | See Notes |
Squirrel Girl 6 Star | Beat Up the Universe | See Notes |
Guardian
Add Guardian to a team with Squirrel Girl to activate the 'On Guard for Thee' synergy bonus which makes the first 3 blocks have a 100% chance to be Perfect Blocks for all Champions except Guardian. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Guardian Synergy with Squirrel Girl
Star | Synergy | Bonus |
---|---|---|
Squirrel Girl 3 Star | On Guard for Thee | See Notes |
Squirrel Girl 4 Star | On Guard for Thee | See Notes |
Squirrel Girl 5 Star | On Guard for Thee | See Notes |
Squirrel Girl 6 Star | On Guard for Thee | See Notes |
Hit-Monkey
Add Hit-Monkey to a team with Squirrel Girl to activate the 'Furry Frenemies' synergy bonus where Critical Hits for Hit-Monkey have a 30% chance to Armor Break the Opponent for 6 seconds, reducing their Armor Rating by 700. For Squirrel Girl the synergy makes them Activate a Combo Shield for 5 seconds when they would otherwise lose their Combo Meter from being struck. Sadly this only activates only once per fight. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Hit-Monkey Synergy with Squirrel Girl
Star | Synergy | Bonus |
---|---|---|
Squirrel Girl 4 Star | Furry Frenemies | See Notes |
Squirrel Girl 5 Star | Furry Frenemies | See Notes |
Squirrel Girl 6 Star | Furry Frenemies | See Notes |
Luke Cage
Adding Squirrel Girl with Luke Cage activates the 'Supernanny' synergy bonus where Squirrel Girl starts the fight with a permanent Fury Buff which increases her Attack Rating by 10% until her Combo Meter reaches 0 hits for any reason and for Luke Cage when he gets hit by the Opponent's Special 3 while he is Indestructible he gains a Fury Buff which increases his Attack Rating by 50% for 15 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Squirrel Girl Synergy with Luke Cage
Star | Synergy | Bonus |
---|---|---|
Squirrel Girl 3 Star | Supernanny | See Notes |
Squirrel Girl 4 Star | Supernanny | See Notes |
Squirrel Girl 5 Star | Supernanny | See Notes |
Squirrel Girl 6 Star | Supernanny | See Notes |
M.O.D.O.K.
Adding Squirrel Girl with M.O.D.O.K. activates the 'Beat Up the Universe' synergy bonus so that once per fight when Tippy Toe would Purify all non-damaging Debuffs on Squirrel Girl it will also Purify 1 damaging Debuff and M.O.D.O.K. gains 10% Attack Rating while fighting Hero Champions. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Squirrel Girl Synergy with M.O.D.O.K.
Star | Synergy | Bonus |
---|---|---|
Squirrel Girl 5 Star | Beat Up the Universe | See Notes |
Squirrel Girl 6 Star | Beat Up the Universe | See Notes |
Mordo
Adding Squirrel Girl with Mordo activates the 'Beat Up the Universe' synergy bonus so that once per fight when Tippy Toe would Purify all non-damaging Debuffs on Squirrel Girl it will also Purify 1 damaging Debuff and Mordo gains 10% Attack Rating while fighting Hero Champions. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Squirrel Girl Synergy with Mordo
Star | Synergy | Bonus |
---|---|---|
Squirrel Girl 5 Star | Beat Up the Universe | See Notes |
Squirrel Girl 6 Star | Beat Up the Universe | See Notes |
Sasquatch
Add Sasquatch to a team with Squirrel Girl to activate the 'Furry Buds' synergy bonus which makes Rupture effects for Sasquatch last 20% longer, plus for Squirrel Girl when Tippy-Toe attaches to the Opponent she stays on for 30% longer. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Sasquatch Synergy with Squirrel Girl
Star | Synergy | Bonus |
---|---|---|
Squirrel Girl 4 Star | Furry Buds | See Notes |
Squirrel Girl 5 Star | Furry Buds | See Notes |
Squirrel Girl 6 Star | Furry Buds | See Notes |
Sentinel
Adding Squirrel Girl with Sentinel activates the 'Hardwired for Heartbreak' synergy bonus where Squirrel Girl converts her Bleed into a Shock effect each time a Robot Opponent is immune to one of her personal Bleed effects. As for Sentinel each time an Opponent is immune to one of his personal Incinerate or Shock effects he gains 2 Analysis Charges. Analysis already Complete? In which case he will deal a burst of 25% of his Attack Rating as Energy Damage each time instead. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Squirrel Girl Synergy with Sentinel
Star | Synergy | Bonus |
---|---|---|
Squirrel Girl 4 Star | Hardwired for Heartbreak | See Notes |
Squirrel Girl 5 Star | Hardwired for Heartbreak | See Notes |
Squirrel Girl 6 Star | Hardwired for Heartbreak | See Notes |
Thanos
Adding Squirrel Girl with Thanos activates the 'Beat Up the Universe' synergy bonus so that once per fight when Tippy Toe would Purify all non-damaging Debuffs on Squirrel Girl it will also Purify 1 damaging Debuff and Thanos gains 10% Attack Rating while fighting Hero Champions. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Squirrel Girl Synergy with Thanos
Star | Synergy | Bonus |
---|---|---|
Squirrel Girl 5 Star | Beat Up the Universe | See Notes |
Squirrel Girl 6 Star | Beat Up the Universe | See Notes |