
Annihilus Synergy Guide
Annihilus is a Cosmic class champion in the Contest of Champions who forms a synergy with 10 other characters, available as a 3-Star, 4-Star and 5-Star champion.
After the Fantastic Four opened a portal to the Negative Zone in search of anti-particles, they encountered Annihilus. A vicious, raving, and paranoid insectoid creature ruling over the Negative Zone. Aided by his most prized possession, the Cosmic Control Rod, Annihilus has waged an all out war on every living thing in the Universe for it's the only way he can ensure nothing can ever threaten his life or his precious Cosmic Control Rod.
Synergy Bonuses
- 'Double Negative' with Darkhawk
- 'Challenger' with Hulk (Ragnarok)
- 'Enemies' with Human Torch or Thing

Darkhawk
Adding Annihilus with Darkhawk activates the 'Double Negative' synergy bonus where Annihilus is Taunted for 0.5 seconds when Striking an Auto Blocking Opponent while Cosmic Control Rod is active. While Taunted, his Attack Rating is reduced by 40% and Darkhawks' Attack Rating is increased by 9% while in any mode. The Contingency Plan is if Annihilus is fighting Darkhawk then Darkhawk's Armor Rating is decreased by 15% while in any mode.

Annihilus Synergy with Darkhawk
Star | Synergy | Bonus |
---|---|---|
Annihilus 4 Star | Double Negative | See Notes |
Annihilus 5 Star | Double Negative | See Notes |
Doctor Doom
Add Doctor Doom to a team with Annihilus to activate the 'Fantastic Rage' synergy bonus where Heavy Attacks for Doctor Doom are guaranteed critical hits while the Opponent is suffering from a Stagger effect. Please note this is a solo synergy which does not stack.

Doctor Doom Synergy with Annihilus
Star | Synergy | Bonus |
---|---|---|
Annihilus 4 Star | Fantastic Rage | See Notes |
Annihilus 5 Star | Fantastic Rage | See Notes |
Hulk (Ragnarok)
Adding Annihilus with Hulk (Ragnarok) activates the 'Challenger' synergy bonus where every time Annihilus' Opponent activates a Fury effect, Annihilus gains an Armor Up Buff increasing Armor Rating by 8% for 4 seconds and Hulk (Ragnarok) gains a Passive Fury boosting attack damage by 12% while Face Me is active. There is a Contingency Plan where whenever Hulk (Ragnarok) Strikes Annihilus with a SMASH attack, Annihilus gains 1 Fury buff increasing Attack Rating by 100% for 4 seconds.

Annihilus Synergy with Hulk (Ragnarok)
Star | Synergy | Bonus |
---|---|---|
Annihilus 3 Star | Challenger | See Notes |
Annihilus 4 Star | Challenger | See Notes |
Annihilus 5 Star | Challenger | See Notes |
Human Torch
Adding Annihilus with Human Torch activates the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Annihilus Synergy with Human Torch
Star | Synergy | Bonus |
---|---|---|
Annihilus 3 Star | Enemies Level 3 | +155 Critical Rating |
Annihilus 4 Star | Enemies Level 3 | +155 Critical Rating |
Annihilus 5 Star | Enemies Level 3 | +155 Critical Rating |
Mole Man
Add Mole Man to a team with Annihilus to activate the 'Fantastic Fiends' synergy bonus so that while Mole Man is Frenzied his attacks lower Defensive Ability Accuracy by 50% when fighting against the #Fantastic Four and Annihilus gets a 20% chance to Purify a Debuff. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mole Man Synergy with Annihilus
Star | Synergy | Bonus |
---|---|---|
Annihilus 3 Star | Fantastic Fiends | See Notes |
Annihilus 4 Star | Fantastic Fiends | See Notes |
Annihilus 5 Star | Fantastic Fiends | See Notes |
Nova
Add Nova to a team with Annihilus to activate the 'Total Annihilation' synergy bonus where Nova gains +40% Perfect Block chance when triggering Auto-Blockand and Annihilus gets +65% Physical Resistance while Unstoppable. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Nova Synergy with Annihilus
Star | Synergy | Bonus |
---|---|---|
Annihilus 3 Star | Total Annihilation | See Notes |
Annihilus 4 Star | Total Annihilation | See Notes |
Annihilus 5 Star | Total Annihilation | See Notes |
She-Hulk
Add She-Hulk to a team with Annihilus to activate the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

She-Hulk Synergy with Annihilus
Star | Synergy | Bonus |
---|---|---|
Annihilus 4 Star | Enemies Level 3 | +155 Critical Rating |
Annihilus 5 Star | Enemies Level 3 | +155 Critical Rating |
Silver Surfer
Add Silver Surfer to a team with Annihilus to activate the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Silver Surfer Synergy with Annihilus
Star | Synergy | Bonus |
---|---|---|
Annihilus 3 Star | Enemies Level 1 | +85 Critical Rating |
Annihilus 4 Star | Enemies Level 2 | +115 Critical Rating |
Annihilus 5 Star | Enemies Level 3 | +155 Critical Rating |
Terrax
Add Terrax to a team with Annihilus to activate the 'Prisoner' synergy bonus which gives Terrax +15% Attack Rating whilst all Fury Buffs for Annihilus last an additional second. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Terrax Synergy with Annihilus
Star | Synergy | Bonus |
---|---|---|
Annihilus 3 Star | Prisoner | See Notes |
Annihilus 4 Star | Prisoner | See Notes |
Annihilus 5 Star | Prisoner | See Notes |
Annihilus 6 Star | Prisoner | See Notes |
Thing
Adding Annihilus with Thing activates the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Annihilus Synergy with Thing
Star | Synergy | Bonus |
---|---|---|
Annihilus 3 Star | Enemies Level 3 | +155 Critical Rating |
Annihilus 4 Star | Enemies Level 3 | +155 Critical Rating |
Annihilus 5 Star | Enemies Level 3 | +155 Critical Rating |