
Medusa Synergy Guide
Medusa is a Cosmic class champion in the Contest of Champions who forms a synergy with 6 other characters, available as a 3-Star, 4-Star and 5-Star champion.
Born into the Inhuman Royal Family of Attilan, Medusa was exposed to the mutagenic Terrigen Mists when she was only an infant. This transformation endowed her with tougher-than-steel hair and the ability to control each strand like an added appendage. Along with her husband, Black Bolt, Medusa leads her people as the Queen of the Inhumans in their search for a better place in the world.
Synergy Bonuses
- 'Inhuman Royal Family' with Black Bolt
- 'Inhuman Royal Family' with Karnak
- 'Enemies' with Wolverine or Iron Man
- 'Rivals' with Quake

Black Bolt
Team Medusa with Black Bolt to create a perfect synergy, with each champion activating their own bonus depending on their star-rating. Medusa activates the 'Inhuman Royal Family' synergy bonus where Medusa has her Living Strands generate up to 6 Fury Buffs and Black Bolt has his Provocation buffs become permanent instead of temporary. Black Bolt adds the 'Family' bonus, increasing 'Health' for the whole team. In addition, if you team Medusa, Black Bolt and Karnak together you get Inhuman Royal Family which increases Attack by +25% at the start of the fight. Please note Inhuman Royal Family is a Unique Synergy which does not stack with duplicate synergies.

Medusa Synergy with Black Bolt
Star | Synergy | Bonus |
---|---|---|
Medusa 4 Star | Inhuman Royal Family | See Notes |
Medusa 5 Star | Inhuman Royal Family | See Notes |

Black Bolt Synergy with Medusa
Star | Synergy | Bonus |
---|---|---|
Medusa 2 Star | Family Level 1 | +4% Health |
Medusa 3 Star | Family Level 2 | +5% Health |
Medusa 4 Star | Family Level 3 | +6% Health |
Medusa 6 Star | Family Level 3 | +6% Health |
Human Torch
Add Human Torch to a team with Medusa to activate the 'Romance' synergy bonus, increasing 'Power Gain' for the whole team.

Human Torch Synergy with Medusa
Star | Synergy | Bonus |
---|---|---|
Medusa 3 Star | Romance Level 2 | +4% Power Gain |
Medusa 4 Star | Romance Level 3 | +5% Power Gain |
Medusa 5 Star | Romance Level 3 | +5% Power Gain |
Medusa 6 Star | Romance Level 3 | +5% Power Gain |
Iron Man
Adding Medusa with Iron Man activates the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Medusa Synergy with Iron Man
Star | Synergy | Bonus |
---|---|---|
Medusa 3 Star | Enemies Level 2 | +115 Critical Rating |
Medusa 4 Star | Enemies Level 3 | +155 Critical Rating |
Medusa 5 Star | Enemies Level 3 | +155 Critical Rating |
Karnak
Team Medusa with Karnak to create a perfect synergy, with each champion activating their own bonus depending on their star-rating. Medusa activates the 'Inhuman Royal Family' synergy bonus where Medusa can inflict up to 4 permanent Armor Breaks with her Heavy Attacks and Karnak becomes Focused 35% faster and his True Strikes last 35% longer. Karnak adds the 'Family' bonus, increasing 'Health' for the whole team. Please note Inhuman Royal Family is a Unique Synergy which does not stack with duplicate synergies.

Medusa Synergy with Karnak
Star | Synergy | Bonus |
---|---|---|
Medusa 3 Star | Inhuman Royal Family | See Notes |
Medusa 4 Star | Inhuman Royal Family | See Notes |
Medusa 5 Star | Inhuman Royal Family | See Notes |

Karnak Synergy with Medusa
Star | Synergy | Bonus |
---|---|---|
Medusa 3 Star | Family Level 2 | +5% Health |
Medusa 4 Star | Family Level 3 | +6% Health |
Medusa 5 Star | Family Level 3 | +6% Health |
Medusa 6 Star | Family Level 3 | +6% Health |
Quake
Adding Medusa with Quake activates the 'Rivals' synergy bonus, increasing 'Critical Damage Rating' for the whole team.

Medusa Synergy with Quake
Star | Synergy | Bonus |
---|---|---|
Medusa 3 Star | Rivals Level 2 | +90 Critical Damage Rating |
Medusa 4 Star | Rivals Level 3 | +115 Critical Damage Rating |
Medusa 5 Star | Rivals Level 3 | +115 Critical Damage Rating |
Wolverine
Adding Medusa with Wolverine activates the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Medusa Synergy with Wolverine
Star | Synergy | Bonus |
---|---|---|
Medusa 3 Star | Enemies Level 2 | +115 Critical Rating |
Medusa 4 Star | Enemies Level 3 | +155 Critical Rating |
Medusa 5 Star | Enemies Level 3 | +155 Critical Rating |