Mysterio Cover

Mysterio Synergy Guide

Mysterio is a Tech class champion in the Contest of Champions who forms a synergy with 13 other characters, available as a 3-Star, 4-Star and 5-Star champion.

Quentin Beck is from an Earth nearly identical to our own. Traveling to our world to battle the very same elemental creatures that destroyed his planet, Beck is quickly established as one of Earth's protectors. Taking on the superhero persona of "Mysterio", he is recruited by Nick Fury alongside Spider-Man to stop the elemental creatures before it's too late and prove his capabilities to the world!

Synergy Bonuses

Synergy Partners

  • DaredevilDaredevil
  • Daredevil (Classic)Daredevil (Classic)
  • Emma FrostEmma Frost
  • Invisible WomanInvisible Woman
  • Night ThrasherNight Thrasher
  • Old Man LoganOld Man Logan
  • Spider-GwenSpider-Gwen
  • Spider-Man (Classic)Spider-Man (Classic)
  • Spider-Man (Miles Morales)Spider-Man (Miles Morales)
  • Spider-Man (Stark Enhanced)Spider-Man (Stark Enhanced)
  • Spider-Man (Stealth Suit)Spider-Man (Stealth Suit)
  • Spider-Man (Symbiote)Spider-Man (Symbiote)
  • Vision (Aarkus)Vision (Aarkus)
Mysterio


Daredevil

Adding Mysterio with activates the 'Encroaching Insanity' synergy bonus which increases the Poison durations by 2 seconds for Mysterio. Please note this is a Solo Synergy which does not stack with duplicate synergies.

Mysterio

Mysterio Synergy with Daredevil

Star Synergy Bonus
Mysterio 3 Star Encroaching Insanity See Notes
Mysterio 4 Star Encroaching Insanity See Notes
Mysterio 5 Star Encroaching Insanity See Notes
Please note: Mysterio can also activate 'Encroaching Insanity' with Daredevil (Classic) as an alternative.

Daredevil (Classic)

Adding Mysterio with activates the 'Encroaching Insanity' synergy bonus which increases the Poison durations by 2 seconds for Mysterio. Please note this is a Solo Synergy which does not stack with duplicate synergies.

Mysterio

Mysterio Synergy with Daredevil (Classic)

Star Synergy Bonus
Mysterio 3 Star Encroaching Insanity See Notes
Mysterio 4 Star Encroaching Insanity See Notes
Mysterio 5 Star Encroaching Insanity See Notes
Please note: Mysterio can also activate 'Encroaching Insanity' with Daredevil as an alternative.

Emma Frost

Adding Mysterio with activates the 'Mental Immunity' synergy bonus which grants both Mysterio and Emma Frost immunity to reverse controls. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mysterio

Mysterio Synergy with Emma Frost

Star Synergy Bonus
Mysterio 4 Star Mental Immunity See Notes
Mysterio 5 Star Mental Immunity See Notes

Invisible Woman

Add to a team with Mysterio to activate the 'Unphased' synergy bonus where synergy members generate 10% of a bar of Power every time the opponent misses. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Invisible Woman

Invisible Woman Synergy with Mysterio

Star Synergy Bonus
Mysterio 4 Star Unphased See Notes
Mysterio 5 Star Unphased See Notes
Mysterio 6 Star Unphased See Notes

Night Thrasher

Adding Mysterio with activates the 'Mine Can Hover' synergy bonus where when Mysterio dashes forward he has a 70% chance to inflict the Opponent with Falter for the duration of the dash. Opponents suffering Falter have a 100% chance to Miss their attacks.. Please note this is a Solo Synergy which does not stack with duplicate synergies.

Mysterio

Mysterio Synergy with Night Thrasher

Star Synergy Bonus
Mysterio 3 Star Mine Can Hover See Notes
Mysterio 4 Star Mine Can Hover See Notes
Mysterio 5 Star Mine Can Hover See Notes

Old Man Logan

Add to a team with Mysterio to activate the 'No…Not You…' synergy bonus where the first time Old Man Logan gains a 0 Damage Passive Bleed each fight, he gains 2 more. Additionally, his Regeneration Rate is increased by +10%. For Mysterio he heals an additional flat +10% health when Regenerating from the use of Reflection Gas. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Old Man Logan

Old Man Logan Synergy with Mysterio

Star Synergy Bonus
Mysterio 4 Star No…Not You… See Notes
Mysterio 5 Star No…Not You… See Notes

Spider-Gwen

Adding Mysterio with activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Mysterio

Mysterio Synergy with Spider-Gwen

Star Synergy Bonus
Mysterio 3 Star Nemesis Level 2 +5% Attack
Mysterio 4 Star Nemesis Level 3 +6% Attack
Mysterio 5 Star Nemesis Level 99 +8% Attack
Please note: Mysterio can also activate 'Nemesis' with Spider-Man (Classic), Spider-Man (Miles Morales), Spider-Man (Stark Enhanced), Spider-Man (Stealth Suit) or Spider-Man (Symbiote) as an alternative.

Spider-Man (Classic)

Adding Mysterio with activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Mysterio

Mysterio Synergy with Spider-Man (Classic)

Star Synergy Bonus
Mysterio 3 Star Nemesis Level 2 +5% Attack
Mysterio 4 Star Nemesis Level 3 +6% Attack
Mysterio 5 Star Nemesis Level 99 +8% Attack
Please note: Mysterio can also activate 'Nemesis' with Spider-Gwen, Spider-Man (Miles Morales), Spider-Man (Stark Enhanced), Spider-Man (Stealth Suit) or Spider-Man (Symbiote) as an alternative.

Spider-Man (Miles Morales)

Adding Mysterio with activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Mysterio

Mysterio Synergy with Spider-Man (Miles Morales)

Star Synergy Bonus
Mysterio 3 Star Nemesis Level 2 +5% Attack
Mysterio 4 Star Nemesis Level 3 +6% Attack
Mysterio 5 Star Nemesis Level 99 +8% Attack
Please note: Mysterio can also activate 'Nemesis' with Spider-Gwen, Spider-Man (Classic), Spider-Man (Stark Enhanced), Spider-Man (Stealth Suit) or Spider-Man (Symbiote) as an alternative.

Spider-Man (Stark Enhanced)

Adding Mysterio with activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Mysterio

Mysterio Synergy with Spider-Man (Stark Enhanced)

Star Synergy Bonus
Mysterio 3 Star Nemesis Level 2 +5% Attack
Mysterio 4 Star Nemesis Level 3 +6% Attack
Mysterio 5 Star Nemesis Level 99 +8% Attack
Please note: Mysterio can also activate 'Nemesis' with Spider-Gwen, Spider-Man (Classic), Spider-Man (Miles Morales), Spider-Man (Stealth Suit) or Spider-Man (Symbiote) as an alternative.

Spider-Man (Stealth Suit)

Team up Mysterio with to activate the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team. If Mysterio is 4 star or higher he also activates the solo synergy 'Enhanced Illusionist' where his Reflection, Illusion and Frenzy Gas last for an additional 2 seconds but alas it does not stack.

Mysterio

Mysterio Synergy with Spider-Man (Stealth Suit)

Star Synergy Bonus
Mysterio 3 Star Nemesis Level 2 +5% Attack
Mysterio 4 Star Nemesis Level 3 + Enhanced Illusionist +6% Attack + See Notes
Mysterio 5 Star Nemesis Level 99 + Enhanced Illusionist +8% Attack + See Notes
Please note: Mysterio can also activate 'Nemesis' with Spider-Gwen, Spider-Man (Classic), Spider-Man (Miles Morales), Spider-Man (Stark Enhanced) or Spider-Man (Symbiote) as an alternative.

Spider-Man (Symbiote)

Adding Mysterio with activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Mysterio

Mysterio Synergy with Spider-Man (Symbiote)

Star Synergy Bonus
Mysterio 3 Star Nemesis Level 2 +5% Attack
Mysterio 4 Star Nemesis Level 3 +6% Attack
Mysterio 5 Star Nemesis Level 99 +8% Attack
Please note: Mysterio can also activate 'Nemesis' with Spider-Gwen, Spider-Man (Classic), Spider-Man (Miles Morales), Spider-Man (Stark Enhanced) or Spider-Man (Stealth Suit) as an alternative.

Vision (Aarkus)

Add to a team with Mysterio to activate the 'Dry Ice' synergy bonus where Vision (Aarkus) increases the duration of his Armor Break Debuffs by 2 seconds flat whilst Mysterio increases the duration of his Reflection and Frenzy gas by 3 seconds flat. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Vision (Aarkus)

Vision (Aarkus) Synergy with Mysterio

Star Synergy Bonus
Mysterio 4 Star Dry Ice See Notes
Mysterio 5 Star Dry Ice See Notes