
Mysterio Synergy Guide
Mysterio is a Tech class champion in the Contest of Champions who forms a synergy with 14 other characters, available as a 3-Star, 4-Star and 5-Star champion.
Quentin Beck is from an Earth nearly identical to our own. Traveling to our world to battle the very same elemental creatures that destroyed his planet, Beck is quickly established as one of Earth's protectors. Taking on the superhero persona of "Mysterio", he is recruited by Nick Fury alongside Spider-Man to stop the elemental creatures before it's too late and prove his capabilities to the world!
Synergy Bonuses
- 'Nemesis' with Spider-Gwen, Spider-Man (Classic), Spider-Man (Miles Morales), Spider-Man (Stark Enhanced), Spider-Man (Stealth Suit) or Spider-Man (Symbiote)
- 'Mental Immunity' with Emma Frost
- 'Enhanced Illusionist' with Spider-Man (Stealth Suit)
- 'Encroaching Insanity' with Daredevil or Daredevil (Classic)
- 'Mine Can Hover' with Night Thrasher

Daredevil
Adding Mysterio with Daredevil activates the 'Encroaching Insanity' synergy bonus which increases the Poison durations by 2 seconds for Mysterio. Please note this is a Solo Synergy which does not stack with duplicate synergies.

Mysterio Synergy with Daredevil
Star | Synergy | Bonus |
---|---|---|
Mysterio 3 Star | Encroaching Insanity | See Notes |
Mysterio 4 Star | Encroaching Insanity | See Notes |
Mysterio 5 Star | Encroaching Insanity | See Notes |
Daredevil (Classic)
Adding Mysterio with Daredevil (Classic) activates the 'Encroaching Insanity' synergy bonus which increases the Poison durations by 2 seconds for Mysterio. Please note this is a Solo Synergy which does not stack with duplicate synergies.

Mysterio Synergy with Daredevil (Classic)
Star | Synergy | Bonus |
---|---|---|
Mysterio 3 Star | Encroaching Insanity | See Notes |
Mysterio 4 Star | Encroaching Insanity | See Notes |
Mysterio 5 Star | Encroaching Insanity | See Notes |
Emma Frost
Adding Mysterio with Emma Frost activates the 'Mental Immunity' synergy bonus which grants both Mysterio and Emma Frost immunity to reverse controls. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Mysterio Synergy with Emma Frost
Star | Synergy | Bonus |
---|---|---|
Mysterio 4 Star | Mental Immunity | See Notes |
Mysterio 5 Star | Mental Immunity | See Notes |
Invisible Woman
Add Invisible Woman to a team with Mysterio to activate the 'Unphased' synergy bonus where synergy members generate 10% of a bar of Power every time the opponent misses. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Invisible Woman Synergy with Mysterio
Star | Synergy | Bonus |
---|---|---|
Mysterio 4 Star | Unphased | See Notes |
Mysterio 5 Star | Unphased | See Notes |
Mysterio 6 Star | Unphased | See Notes |
Night Thrasher
Adding Mysterio with Night Thrasher activates the 'Mine Can Hover' synergy bonus where when Mysterio dashes forward he has a 70% chance to inflict the Opponent with Falter for the duration of the dash. Opponents suffering Falter have a 100% chance to Miss their attacks.. Please note this is a Solo Synergy which does not stack with duplicate synergies.

Mysterio Synergy with Night Thrasher
Star | Synergy | Bonus |
---|---|---|
Mysterio 3 Star | Mine Can Hover | See Notes |
Mysterio 4 Star | Mine Can Hover | See Notes |
Mysterio 5 Star | Mine Can Hover | See Notes |
Old Man Logan
Add Old Man Logan to a team with Mysterio to activate the 'No…Not You…' synergy bonus where the first time Old Man Logan gains a 0 Damage Passive Bleed each fight, he gains 2 more. Additionally, his Regeneration Rate is increased by +10%. For Mysterio he heals an additional flat +10% health when Regenerating from the use of Reflection Gas. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Old Man Logan Synergy with Mysterio
Star | Synergy | Bonus |
---|---|---|
Mysterio 4 Star | No…Not You… | See Notes |
Mysterio 5 Star | No…Not You… | See Notes |
Silver Surfer
Add Silver Surfer to a team with Mysterio to activate the 'Mine Travels Through Space' synergy bonus which makes board attacks for Silver Surfer generate 30% less Power for the Opponent whilst Mysterio’s advantages against Spider-Verse champions extends to all Hero Champions. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Silver Surfer Synergy with Mysterio
Star | Synergy | Bonus |
---|---|---|
Mysterio 4 Star | Mine Travels Through Space | See Notes |
Mysterio 5 Star | Mine Travels Through Space | See Notes |
Spider-Gwen
Adding Mysterio with Spider-Gwen activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Mysterio Synergy with Spider-Gwen
Star | Synergy | Bonus |
---|---|---|
Mysterio 3 Star | Nemesis Level 2 | +5% Attack |
Mysterio 4 Star | Nemesis Level 3 | +6% Attack |
Mysterio 5 Star | Nemesis Level 99 | +8% Attack |
Spider-Man (Classic)
Adding Mysterio with Spider-Man (Classic) activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Mysterio Synergy with Spider-Man (Classic)
Star | Synergy | Bonus |
---|---|---|
Mysterio 3 Star | Nemesis Level 2 | +5% Attack |
Mysterio 4 Star | Nemesis Level 3 | +6% Attack |
Mysterio 5 Star | Nemesis Level 99 | +8% Attack |
Spider-Man (Miles Morales)
Adding Mysterio with Spider-Man (Miles Morales) activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Mysterio Synergy with Spider-Man (Miles Morales)
Star | Synergy | Bonus |
---|---|---|
Mysterio 3 Star | Nemesis Level 2 | +5% Attack |
Mysterio 4 Star | Nemesis Level 3 | +6% Attack |
Mysterio 5 Star | Nemesis Level 99 | +8% Attack |
Spider-Man (Stark Enhanced)
Adding Mysterio with Spider-Man (Stark Enhanced) activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Mysterio Synergy with Spider-Man (Stark Enhanced)
Star | Synergy | Bonus |
---|---|---|
Mysterio 3 Star | Nemesis Level 2 | +5% Attack |
Mysterio 4 Star | Nemesis Level 3 | +6% Attack |
Mysterio 5 Star | Nemesis Level 99 | +8% Attack |
Spider-Man (Stealth Suit)
Team up Mysterio with Spider-Man (Stealth Suit) to activate the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team. If Mysterio is 4 star or higher he also activates the solo synergy 'Enhanced Illusionist' where his Reflection, Illusion and Frenzy Gas last for an additional 2 seconds but alas it does not stack.

Mysterio Synergy with Spider-Man (Stealth Suit)
Star | Synergy | Bonus |
---|---|---|
Mysterio 3 Star | Nemesis Level 2 | +5% Attack |
Mysterio 4 Star | Nemesis Level 3 + Enhanced Illusionist | +6% Attack + See Notes |
Mysterio 5 Star | Nemesis Level 99 + Enhanced Illusionist | +8% Attack + See Notes |
Spider-Man (Symbiote)
Adding Mysterio with Spider-Man (Symbiote) activates the 'Nemesis' synergy bonus, increasing 'Attack' for the whole team.

Mysterio Synergy with Spider-Man (Symbiote)
Star | Synergy | Bonus |
---|---|---|
Mysterio 3 Star | Nemesis Level 2 | +5% Attack |
Mysterio 4 Star | Nemesis Level 3 | +6% Attack |
Mysterio 5 Star | Nemesis Level 99 | +8% Attack |
Vision (Aarkus)
Add Vision (Aarkus) to a team with Mysterio to activate the 'Dry Ice' synergy bonus where Vision (Aarkus) increases the duration of his Armor Break Debuffs by 2 seconds flat whilst Mysterio increases the duration of his Reflection and Frenzy gas by 3 seconds flat. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Vision (Aarkus) Synergy with Mysterio
Star | Synergy | Bonus |
---|---|---|
Mysterio 4 Star | Dry Ice | See Notes |
Mysterio 5 Star | Dry Ice | See Notes |
Mysterio 6 Star | Dry Ice | See Notes |