Professor X Cover

Professor X Synergy Guide

Professor X is a Mutant class champion in the Contest of Champions who forms a synergy with 16 other characters, available as a 2-Star, 3-Star, 4-Star, 5-Star and 6-Star champion.

Professor X believed in peaceful coexistence of mutants and humans, but this all changed when Moira MacTaggert revealed to him the inevitable demise of mutantkind, unless Professor X could change his ways. Under the new moniker "X", he gave up his old dreams. No more would mutants endure the afflictions and prejudice of humankind. Under the formidable rule of X, the mutant nation of Krakoa was founded. And those who defy the nation must enter the Mindscape and face Professor X in a duel of mental strength.

Synergy Bonuses

Synergy Partners

  • Archangel
  • Beast
  • Colossus
  • Cyclops (Blue Team)
  • Cyclops (New Xavier School)
  • Emma Frost
  • Iceman
  • Magneto
  • Magneto (Marvel Now)
  • Nightcrawler
  • Phoenix
  • Professor X
  • Storm
  • Storm (Pyramid X)
  • Wolverine
  • Wolverine X-23
Professor X


Archangel

Adding Professor X with activates the 'Gateway' synergy bonus where all Mutants and X-Men except Professor X gain 6% of a bar of Power every 10 seconds for each Cerebro Charge up to a maximum of 24%. In addition Archangel gets +30% Bleed Potency. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Archangel

Star Synergy Bonus
Professor X 4 Star Gateway See Notes
Professor X 5 Star Gateway See Notes
Professor X 6 Star Gateway See Notes
Please note: Professor X can also activate 'Gateway' with Beast or Nightcrawler as an alternative.

Beast

Adding Professor X with activates the 'Gateway' synergy bonus where all Mutants and X-Men except Professor X gain 6% of a bar of Power every 10 seconds for each Cerebro Charge up to a maximum of 24%. In addition Beast increases the duration of Freestyle and Acrobatic Combo Success by 5 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Beast

Star Synergy Bonus
Professor X 4 Star Gateway See Notes
Professor X 5 Star Gateway See Notes
Professor X 6 Star Gateway See Notes
Please note: Professor X can also activate 'Gateway' with Archangel or Nightcrawler as an alternative.

Colossus

Adding Professor X with activates the 'Drug I' synergy bonus where all Mutants and X-Men except Professor X gain +18% Poison Resistance for each Cerebro Charge up to a maximum of 72%. In addition Colossus gets to start each fight with 1 indefinite Armor Up Buff, granting +15% Armor Rating. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Colossus

Star Synergy Bonus
Professor X 3 Star Drug I See Notes
Professor X 4 Star Drug I See Notes
Professor X 5 Star Drug I See Notes
Professor X 6 Star Drug I See Notes
Please note: Professor X can also activate 'Drug I' with Wolverine or Wolverine X-23 as an alternative.

Cyclops (Blue Team)

Adding Professor X with activates the 'Drug L' synergy bonus where for all Mutants and X-Men except Professor X once per fight when they would be knocked out they will instead regenerate 7.5% of their Max Health for each Cerebro Charge up to a maximum of 30% Health. In addition Beam Hits for Cyclops gain +100% Critical Damage Rating and inflict an Armor Break, reducing Armor Rating by 20% for 5 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Cyclops (Blue Team)

Star Synergy Bonus
Professor X 4 Star Drug L See Notes
Professor X 5 Star Drug L See Notes
Professor X 6 Star Drug L See Notes
Please note: Professor X can also activate 'Drug L' with Cyclops (New Xavier School) or Phoenix as an alternative.

Cyclops (New Xavier School)

Adding Professor X with activates the 'Drug L' synergy bonus where for all Mutants and X-Men except Professor X once per fight when they would be knocked out they will instead regenerate 7.5% of their Max Health for each Cerebro Charge up to a maximum of 30% Health. In addition Beam Hits for Cyclops gain +100% Critical Damage Rating and inflict an Armor Break, reducing Armor Rating by 20% for 5 seconds. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Cyclops (New Xavier School)

Star Synergy Bonus
Professor X 4 Star Drug L See Notes
Professor X 5 Star Drug L See Notes
Professor X 6 Star Drug L See Notes
Please note: Professor X can also activate 'Drug L' with Cyclops (Blue Team) or Phoenix as an alternative.

Emma Frost

Adding Professor X with activates the 'Habitat' synergy bonus where all Mutants and X-Men except Professor X gain +15% Prowess Effect Duration for each Cerebro Charge up to a maximum of 60%. In addition Emma Frost gains up to 30% increased Critical Rating scaling with her Power Meter. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Emma Frost

Star Synergy Bonus
Professor X 3 Star Habitat See Notes
Professor X 4 Star Habitat See Notes
Professor X 5 Star Habitat See Notes
Professor X 6 Star Habitat See Notes
Please note: Professor X can also activate 'Habitat' with Storm or Storm (Pyramid X) as an alternative.

Iceman

Adding Professor X with activates the 'Drug M' synergy bonus where all Mutants and X-Men except Professor X gain a Mental Barrier with 2.5% of Current Health for each Cerebro Charge up to a maximum of Health. Whenever the Champion would take damage except from Special 3 Attacks, the Barrier takes 75% of the damage until it reaches 0 Health. In addition for Iceman when his Ice Armor shatters all Frostbite Effects expire instantly. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Iceman

Star Synergy Bonus
Professor X 5 Star Drug M See Notes
Professor X 6 Star Drug M See Notes
Please note: Professor X can also activate 'Drug M' with Magneto or Magneto (Marvel Now) as an alternative.

Magneto

Adding Professor X with activates the 'Drug M' synergy bonus where all Mutants and X-Men except Professor X gain a Mental Barrier with 2.5% of Current Health for each Cerebro Charge up to a maximum of Health. Whenever the Champion would take damage except from Special 3 Attacks, the Barrier takes 75% of the damage until it reaches 0 Health. In addition Magneto gains +15% Attack Rating while fighting #Metal Champions. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Magneto

Star Synergy Bonus
Professor X 5 Star Drug M See Notes
Professor X 6 Star Drug M See Notes
Please note: Professor X can also activate 'Drug M' with Magneto (Marvel Now) or Iceman as an alternative.

Magneto (Marvel Now)

Adding Professor X with activates the 'Drug M' synergy bonus where all Mutants and X-Men except Professor X gain a Mental Barrier with 2.5% of Current Health for each Cerebro Charge up to a maximum of Health. Whenever the Champion would take damage except from Special 3 Attacks, the Barrier takes 75% of the damage until it reaches 0 Health. In addition the Guidance’s bonus Attack Rating for Magneto (Marvel Now) is increased by a flat +5% or +15% on the final node of a quest. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Magneto (Marvel Now)

Star Synergy Bonus
Professor X 5 Star Drug M See Notes
Professor X 6 Star Drug M See Notes
Please note: Professor X can also activate 'Drug M' with Magneto or Iceman as an alternative.

Nightcrawler

Adding Professor X with activates the 'Gateway' synergy bonus where all Mutants and X-Men except Professor X gain 6% of a bar of Power every 10 seconds for each Cerebro Charge up to a maximum of 24%. In addition Nightcrawler gets +30% Bleed Potency. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Nightcrawler

Star Synergy Bonus
Professor X 4 Star Gateway See Notes
Professor X 5 Star Gateway See Notes
Professor X 6 Star Gateway See Notes
Please note: Professor X can also activate 'Gateway' with Archangel or Beast as an alternative.

Phoenix

Adding Professor X with activates the 'Drug L' synergy bonus where for all Mutants and X-Men except Professor X once per fight when they would be knocked out they will instead regenerate 7.5% of their Max Health for each Cerebro Charge up to a maximum of 30% Health. In addition when Phoenix is Overloaded she gains and indefinite Fury Passive, increasing her Attack Rating by 60% (Max 5 stacks). Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Phoenix

Star Synergy Bonus
Professor X 4 Star Drug L See Notes
Professor X 5 Star Drug L See Notes
Professor X 6 Star Drug L See Notes
Please note: Professor X can also activate 'Drug L' with Cyclops (Blue Team) or Cyclops (New Xavier School) as an alternative.

Professor X

A totally unique synergy for Professor X, no partner required, simply add Professor X to your team to activate the Birthright bonus where all Mutants and X-Men except Professor X get +25% Special Attack Damage for each Cerebro Charge up to Max 100%. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Professor X

Star Synergy Bonus
Professor X 2 Star Birthright See Notes
Professor X 3 Star Birthright See Notes
Professor X 4 Star Birthright See Notes
Professor X 5 Star Birthright See Notes
Professor X 6 Star Birthright See Notes

Storm

Adding Professor X with activates the 'Habitat' synergy bonus where all Mutants and X-Men except Professor X gain +15% Prowess Effect Duration for each Cerebro Charge up to a maximum of 60%. In addition Storm gets +20% Shock Potency. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Storm

Star Synergy Bonus
Professor X 3 Star Habitat See Notes
Professor X 4 Star Habitat See Notes
Professor X 5 Star Habitat See Notes
Professor X 6 Star Habitat See Notes
Please note: Professor X can also activate 'Habitat' with Storm (Pyramid X) or Emma Frost as an alternative.

Storm (Pyramid X)

Adding Professor X with activates the 'Habitat' synergy bonus where all Mutants and X-Men except Professor X gain +15% Prowess Effect Duration for each Cerebro Charge up to a maximum of 60%. In addition Storm (Pyramid X) gets +20% Shock Potency. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Storm (Pyramid X)

Star Synergy Bonus
Professor X 3 Star Habitat See Notes
Professor X 4 Star Habitat See Notes
Professor X 5 Star Habitat See Notes
Professor X 6 Star Habitat See Notes
Please note: Professor X can also activate 'Habitat' with Storm or Emma Frost as an alternative.

Wolverine

Adding Professor X with activates the 'Drug I' synergy bonus where all Mutants and X-Men except Professor X gain +18% Poison Resistance for each Cerebro Charge up to a maximum of 72%. In addition Wolverine gets +15% Crit Rating. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Wolverine

Star Synergy Bonus
Professor X 3 Star Drug I See Notes
Professor X 4 Star Drug I See Notes
Professor X 5 Star Drug I See Notes
Professor X 6 Star Drug I See Notes
Please note: Professor X can also activate 'Drug I' with Wolverine X-23 or Colossus as an alternative.

Wolverine X-23

Adding Professor X with activates the 'Drug I' synergy bonus where all Mutants and X-Men except Professor X gain +18% Poison Resistance for each Cerebro Charge up to a maximum of 72%. In addition Wolverine (X-23) gets +15% Crit Rating. Please note this is a Unique Synergy which does not stack with duplicate synergies.

Professor X

Professor X Synergy with Wolverine X-23

Star Synergy Bonus
Professor X 3 Star Drug I See Notes
Professor X 4 Star Drug I See Notes
Professor X 5 Star Drug I See Notes
Professor X 6 Star Drug I See Notes
Please note: Professor X can also activate 'Drug I' with Wolverine or Colossus as an alternative.