Medusa Cover

Medusa Synergy Guide

Medusa is a Cosmic class champion who forms a synergy with 5 other characters, available as a 3-Star, 4-Star and 5-Star champion.

Born into the Inhuman Royal Family of Attilan, Medusa was exposed to the mutagenic Terrigen Mists when she was only an infant. This transformation endowed her with tougher-than-steel hair and the ability to control each strand like an added appendage. Along with her husband, Black Bolt, Medusa leads her people as the Queen of the Inhumans in their search for a better place in the world.

Synergy Bonuses

Synergy Partners

  • Black BoltBlack Bolt
  • Iron ManIron Man
  • KarnakKarnak
  • QuakeQuake
  • WolverineWolverine
Medusa


Black Bolt

Team Medusa with to create a perfect synergy, with each champion activating their own bonus depending on their star-rating. Medusa activates the 'Inhuman Royal Family' synergy bonus where Medusa has her Living Strands generate up to 6 Fury Buffs and Black Bolt has his Provocation buffs become permanent instead of temporary, whilst Black Bolt adds the 'Family' bonus, increasing 'Health' for the whole team. In addition, if you team Medusa, Black Bolt and Karnak together you get Inhuman Royal Family which increases Attack by +25% at the start of the fight. Please note Inhuman Royal Family is a Unique Synergy which does not stack with duplicate synergies.

Medusa

Medusa Synergy with Black Bolt

Star Synergy Bonus
Medusa 4 Star Inhuman Royal Family See Notes
Medusa 5 Star Inhuman Royal Family See Notes
Black Bolt

Black Bolt Synergy with Medusa

Star Synergy Bonus
Black Bolt 2 Star Family Level 1 +4% Health
Black Bolt 3 Star Family Level 2 +5% Health
Black Bolt 4 Star Family Level 3 +6% Health
Black Bolt 6 Star Family Level 3 +6% Health

Iron Man

Adding Medusa with activates the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Medusa

Medusa Synergy with Iron Man

Star Synergy Bonus
Medusa 3 Star Enemies Level 2 +115 Critical Rating
Medusa 4 Star Enemies Level 3 +155 Critical Rating
Medusa 5 Star Enemies Level 3 +155 Critical Rating
Please note: Medusa can also activate 'Enemies' with Wolverine as an alternative.

Karnak

Team Medusa with to create a perfect synergy, with each champion activating their own bonus depending on their star-rating. Medusa activates the 'Inhuman Royal Family' synergy bonus where Medusa can inflict up to 4 permanent Armor Breaks with her Heavy Attacks and Karnak becomes Focused 35% faster and his True Strikes last 35% longer, whilst Karnak adds the 'Family' bonus, increasing 'Health' for the whole team. Please note Inhuman Royal Family is a Unique Synergy which does not stack with duplicate synergies.

Medusa

Medusa Synergy with Karnak

Star Synergy Bonus
Medusa 3 Star Inhuman Royal Family See Notes
Medusa 4 Star Inhuman Royal Family See Notes
Medusa 5 Star Inhuman Royal Family See Notes
Karnak

Karnak Synergy with Medusa

Star Synergy Bonus
Karnak 3 Star Family Level 2 +5% Health
Karnak 4 Star Family Level 3 +6% Health
Karnak 5 Star Family Level 3 +6% Health
Karnak 6 Star Family Level 3 +6% Health

Quake

Adding Medusa with activates the 'Rivals' synergy bonus, increasing 'Critical Damage Rating' for the whole team.

Medusa

Medusa Synergy with Quake

Star Synergy Bonus
Medusa 3 Star Rivals Level 2 +90 Critical Damage Rating
Medusa 4 Star Rivals Level 3 +115 Critical Damage Rating
Medusa 5 Star Rivals Level 3 +115 Critical Damage Rating

Wolverine

Adding Medusa with activates the 'Enemies' synergy bonus, increasing 'Critical Rating' for the whole team.

Medusa

Medusa Synergy with Wolverine

Star Synergy Bonus
Medusa 3 Star Enemies Level 2 +115 Critical Rating
Medusa 4 Star Enemies Level 3 +155 Critical Rating
Medusa 5 Star Enemies Level 3 +155 Critical Rating
Please note: Medusa can also activate 'Enemies' with Iron Man as an alternative.